Establishment of a National Surgical Tissue Biobank for Pediatric Crohn's Disease: An Implementation Feasibility Study

jpedsurg.org

Crohn's disease (CD) is a lifelong gastrointestinal inflammatory condition that often requires surgery, particularly for patients diagnosed in childhood. CD has been linked to a combination of microbial, genetic, and environmental factors, but pathogenesis remains unknown. We outline a framework for multicenter surgical biobanking across a large geographic area, required to enable meaningful research, and evaluate feasibility using the 2016 Consolidated Standards of Reporting Trials (CONSORT) extension to randomized pilot and feasibility trials.

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Article · Jan 2025 · 1 min read

In brief

This feasibility study describes the establishment of a national surgical tissue biobank for pediatric Crohn's disease patients. The framework enables multicenter collection of surgical specimens across a large geographic area to support research into the microbial, genetic, and environmental factors underlying CD pathogenesis.

Pediatric Crohn's disease frequently requires surgical intervention, making operative tissue a valuable research resource.
CD pathogenesis involves microbial, genetic, and environmental factors but remains incompletely understood.
Multicenter biobanking frameworks are essential to collect sufficient surgical specimens for meaningful research.
This study demonstrates feasibility of national-scale pediatric surgical tissue collection using CONSORT pilot trial standards.
Standardized biobanking protocols enable collaborative research across large geographic areas in rare pediatric conditions.

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