Improved mortality in gastroschisis patients after implementation of a standardized management bundle in central Malawi: A single-center follow-up at four years

jpedsurg.org

Gastroschisis is a congenital anomaly with >90 % survival in high-income countries. Despite advances in neonatal care, survival remains below 20 % in much of sub-Saharan Africa. We evaluate temporal changes in mortality and current predictors of mortality after implementing a standardized care bundle at a tertiary facility in Malawi.

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Article · Aug 2025 · 1 min read

In brief

This study demonstrates improved survival outcomes for gastroschisis patients in Malawi following implementation of a standardized management protocol at a tertiary center. The research addresses the significant mortality gap between high-income countries (>90% survival) and sub-Saharan Africa (<20% survival), evaluating predictors of mortality over a four-year period.

Standardized care bundles can dramatically improve gastroschisis survival in resource-limited settings in sub-Saharan Africa.
Gastroschisis mortality remains >80% in much of sub-Saharan Africa despite >90% survival in high-income countries.
Implementation of protocolized neonatal care at a Malawi tertiary center reduced gastroschisis mortality over four years.
Identifying modifiable predictors of mortality is critical to closing the survival gap for congenital anomalies in low-resource settings.

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