Is It Time to Introduce Ex-Situ Normothermic Machine Perfusion in Paediatric Liver Transplantation?

jpedsurg.org

The clinical use of normothermic machine perfusion in liver transplantation currently excludes paediatric recipients due to the challenges of perfusing smaller grafts and risk of portal hyperperfusion injury. This study aimed to evaluate the haemodynamic conditions and histological changes of left lateral segment grafts (LLSG) during long-term normothermic machine perfusion (LT-NMP).

jpedsurg.org shows its articles on its own site.

Read the article on jpedsurg.org ↗

Article · Feb 2025 · 1 min read

In brief

This study investigates whether normothermic machine perfusion technology can be safely adapted for pediatric liver transplantation by examining left lateral segment grafts during extended perfusion. The research addresses current barriers including technical challenges with smaller grafts and concerns about portal hyperperfusion injury that have prevented use in children.

Normothermic machine perfusion is not yet used in pediatric liver transplants due to technical challenges with smaller grafts.
Portal hyperperfusion injury is a key risk when perfusing left lateral segment grafts used in pediatric recipients.
This study evaluates whether long-term NMP can safely preserve smaller liver grafts for children.
Haemodynamic monitoring and histological assessment are critical to adapting NMP technology for pediatric use.

Written by the GCMD Library team from the article.

Read it at the source ↗