Lymphangioma Circumscriptum of the tongue in paediatric patients: a clinic-pathological and immunohistochemical study with High-Tech protocol and comprehensive literature analysis

jpedsurg.org

Vascular anomalies (VAs) encompass a heterogeneous group of congenital disorders characterized by variable clinical presentations, biological behaviour, and therapeutic responses. The classification system developed by International Society for the Study of Vascular Anomalies (ISSVA) is currently the global standard, categorizing VAs based on histopathological features, hemodynamic, and clinical progression. Lymphatic malformations (LMs), including Lymphangioma Circumscriptum (LC)—a localized, often superficial variant—are stratified into macrocystic, microcystic, or mixed subtypes.

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Article · Jul 2025 · 1 min read

In brief

This study examines lymphangioma circumscriptum affecting the pediatric tongue through advanced immunohistochemical analysis and comprehensive literature review. The work applies ISSVA classification standards to characterize this rare superficial lymphatic malformation variant, providing clinicopathological insights for diagnosis and management in children.

ISSVA classification is the global standard for vascular anomalies, based on histopathology, hemodynamics, and clinical progression.
Lymphatic malformations are categorized into macrocystic, microcystic, or mixed subtypes for treatment planning.
Lymphangioma Circumscriptum is a localized, superficial variant of lymphatic malformation requiring specialized diagnosis.
Vascular anomalies show heterogeneous clinical presentations requiring individualized therapeutic approaches.
Immunohistochemical studies are essential for accurate diagnosis and classification of pediatric tongue lymphangiomas.

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