Ovotesticular Disorders of Sexual Development: Diagnostic, Therapeutic, and Evolutionary Aspects

In brief

This article examines ovotesticular disorders of sexual development, a rare form of DSD where individuals have both ovarian and testicular tissue. The study reviews diagnostic approaches, treatment strategies, and long-term outcomes for patients with OT-DSD, providing insights for pediatric endocrinologists and urologists managing these complex cases.

• Ovotesticular DSD involves presence of both ovarian and testicular tissue in the same individual
• Diagnosis requires histological confirmation of both tissue types, often through gonadal biopsy
• Management is multidisciplinary: endocrinology, surgery, genetics, psychology, and ethics
• Surgical decisions depend on predominant gonadal tissue, phenotype, and family preferences
• Long-term follow-up essential for fertility potential, hormone replacement, and psychosocial support

Written by the GCMD Library team from the article.