Perinatal prognostic factors of recurrence or functional sequelae in neonatal sacrococcygeal teratoma, and implications for prenatal counselling: a multicenter retrospective study.

jpedsurg.org

With an estimated prevalence of 1/40,000-1/10,000 births and a sex ratio of four female for one male [1–3], sacrococcygeal teratoma (SCT) is the most frequent tumor encountered in the fetus and neonate. SCT is an archetypical example of the links between congenital malformations and tumorigenesis in children. It is defined by the presence, in the sacrococcygeal region, of at least two tissues originating from the three primitive embryonic layers, with possible various degrees of maturation [4].

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Article · Sep 2025 · 1 min read

In brief

This multicenter study examines perinatal prognostic factors affecting recurrence and functional outcomes in neonatal sacrococcygeal teratoma, the most common fetal and neonatal tumor. Findings aim to improve prenatal counseling for families facing this rare congenital condition that affects approximately 1 in 10,000-40,000 births.

SCT prevalence is 1/10,000-1/40,000 births with 4:1 female predominance, making it the most common fetal/neonatal tumor.
SCT is defined by presence of ≥2 tissues from all 3 embryonic germ layers in the sacrococcygeal region.
SCT exemplifies the link between congenital malformations and pediatric tumorigenesis.
Degree of tissue maturation in SCT varies, impacting prognosis and recurrence risk.

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