Prognostic Value of Fetal Left Ventricular Myocardial Performance Index for Mortality or ECMO in Congenital Diaphragmatic Hernia

jpedsurg.org

We aimed to determine whether fetal left ventricular myocardial performance index (LV MPI) at 30–34 weeks’ gestation predicts mortality or need for extracorporeal membrane oxygenation (ECMO) in congenital diaphragmatic hernia (CDH), and whether it adds predictive value beyond the observed-to-expected lung-to-head ratio (O/E LHR).

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Article · Oct 2025 · 1 min read

In brief

This study evaluates whether fetal left ventricular myocardial performance index measured in the third trimester can predict mortality or ECMO requirement in infants with congenital diaphragmatic hernia. The research examines if this cardiac function marker provides additional prognostic information beyond the standard lung-to-head ratio used in CDH risk stratification.

Fetal LV MPI at 30-34 weeks gestation may predict mortality or ECMO need in CDH patients.
Study evaluates whether LV MPI adds predictive value beyond the established O/E LHR metric.
Cardiac function assessment via MPI could improve prenatal risk stratification in CDH.
Timing of assessment (30-34 weeks) targets late second/early third trimester for prognostic utility.
Combining cardiac and pulmonary metrics may enhance outcome prediction in CDH.

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