Topical Mitomycin C Application Versus Intralesional Corticosteroid Injection in the Management of Caustic Esophageal Strictures in Pediatrics: A Randomized Controlled Trial

jpedsurg.org

Caustic esophageal strictures in children are difficult to manage and often require multiple endoscopic dilatation sessions or esophageal replacement. Although topical mitomycin C (MMC) treatment and intralesional corticosteroid injection have been suggested as adjuvant therapy to enhance results, there is currently little comparative data in pediatrics.

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Article · Dec 2025 · 1 min read

In brief

This randomized controlled trial compares topical mitomycin C versus intralesional corticosteroid injection as adjuvant therapies for managing caustic esophageal strictures in pediatric patients. Both treatments aim to reduce the need for repeated endoscopic dilatations or esophageal replacement surgery in children with chemical injury-related strictures.

Caustic esophageal strictures in children typically require multiple endoscopic dilatations or esophageal replacement surgery.
Topical mitomycin C and intralesional corticosteroids are emerging adjuvant therapies to reduce stricture recurrence.
Comparative pediatric data on MMC versus corticosteroid efficacy remains limited, highlighting need for controlled trials.

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