Aerodigestive / ENT
To make a definitive clinical diagnosis of CHARGE syndrome, you need either 3 major features and at least 1 minor feature, or 2 major features and 2 minor features, or the CHD7 mutation. QUAD #22: What is CHARGE syndrome? with Dr. Catherine Hart · 0:41
Recovery of lipid-laden macrophages depends on what material was aspirated, how much lipid it contained, the amount aspirated, and how long since the aspiration event. — Bob, Aerodigestive & Esophageal Surgery: Aspiration in TEFs · 3:35
Unrepaired single ventricle patients are sensitive to changes in ventilation because they can have swings in circulation direction based on pulmonary vascular resistance. — Nathan Tighe, QUAD #7 Anesthesia for Thoracoscopic Techniques with Dr. Nathaniel Tighe · 5:55
The new GERD guidelines (joint North America and Europe) recommend treating with PPI for 2 months then attempting to wean, with goal of weaning twice yearly. — Rachel Rosen, Gastroesophageal Reflux Disease · 43:42
The formula for balloon sizing is to take the outer diameter of an age-appropriate endotracheal tube and add one millimeter for the larynx or two millimeters for the trachea. — Michael Rutter, Laryngotracheal Stenosis · 10:55
Pharyngeal stenosis patients warrant long-term surveillance as there is suggestion they may be at increased risk for malignancy, and surveillance for neoplasm development is helpful — Douglas von Allmen, QUAD #5 Pharyngeal Scar Management with Dr. Doug von Allmen · 6:11
In experienced hands who have done numerous or hundreds of these type procedures, tracheobronchopexy can have very good outcomes for patients with severe airway collapse symptoms — George W. Holcomb III, Journal of Pediatric Surgery Article Review: 2nd Quarter (Apr-Jun) 2025 · 3:14
Button batteries can cause ongoing tissue injury for weeks after ingestion, even if 'dead' (they retain ~2 volts); institutional protocol mandates removal within 2 hours of identification. — Michael Rutter, Aerodigestive & Esophageal Surgery - Difficult Tracheal Esophageal Fistula · 53:37
Flexible bronchoscopy is used starting in the nose and ending in the subsegmental bronchi, and bronchoalveolar lavage helps with identification of infections and markers of aspiration. — Sherry Torres Silva, QUAD #27 - Multidisciplinary - How Do Teams Enhance Outcomes by the CCHMC ADEC Team · 8:49
CHARGE syndrome is a rare genetic disorder caused by a CHD7 mutation on chromosome 8. The acronym represents coloboma, heart defects, atresia of the choana, retardation of growth and development, genital and/or urinary anomalies, and ear malformations. Diagnosis can be established based on clinical criteria even without confirmed CHD7 mutation testing. Notably, 80–90% of children with CHARGE syndrome will experience aspiration at some point in their lifetime, making it a significant functional/neurological cause of aspiration risk in the pediatric population.
Tracheopexy is indicated for patients with tracheomalacia who require surgical intervention. Clinical decision-making has evolved to determine which patients will respond best to tracheopexy versus aortopexy using preoperative dynamic studies. The procedure is primarily used in non-esophageal atresia patients. Both aortopexy and tracheopexy are beneficial for tracheomalacia; preoperative dynamic imaging guides selection of the most appropriate procedure for each patient.
- Infants with vomiting/wheezing more often have oropharyngeal dysphagia than GERD; PPIs are ineffective and harmful under age 1. [e289-c1, e289-c3, e289-c5, e359-c1, e359-c3, e359-c5]
- 10% of children <5 with respiratory symptoms have EoE (chronic cough, not dysphagia); never wrap without scoping. Dairy is the allergen in 60–70%. [e289-c6, e289-c7, e289-c8, e289-c9, e359-c6, e359-c7, e359-c9, e359-c11]
- Flexible bronchoscopy misses laryngeal clefts 95% of the time; rigid bronchoscopy with probing of the posterior commissure is required. [e739-c26]
