Bailey Roberts

124 statements · 2 topics

Sarcoma (Ewing/Rhabdo) · guest expert

Featured statements

Extracellular vesicles can cause metastatic spread and therefore be a therapeutic target for osteosarcoma metastasis.
quote · Osteosarcoma
Extracellular vesicles or EVs are small nanoparticles released from all cells.
quote · Osteosarcoma
Osteosarcoma is a malignant pediatric tumor of the bone.
quote · Sarcoma (Ewing/Rhabdo)
Surgically removing the primary tumor is the current standard of care for osteosarcoma
guideline · Sarcoma (Ewing/Rhabdo)

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Bailey's statements about Osteosarcoma 62 statements

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Bailey Roberts, MD - Best of the Best in Pediatric Surgery 2024

Quotation Osteosarcoma is a malignant pediatric tumor of the bone. Open
Quotation Osteosarcoma is a malignant pediatric tumor of the bone. Open
Statement Osteosarcoma most commonly affects adolescents and young adults Open
Statement Osteosarcoma most commonly affects adolescents and young adults Open
Statement The most common site of metastasis in osteosarcoma is in the lung Open
Statement Gross metastasis at the time of diagnosis is present about 20% of the time in osteosarcoma Open
Statement Gross metastasis at the time of diagnosis is present about 20% of the time in osteosarcoma Open
Statement The most common site of metastasis in osteosarcoma is in the lung Open
Statement Overall survival in osteosarcoma worsens from 80% to about 20% for metastatic disease Open
Statement Overall survival in osteosarcoma worsens from 80% to about 20% for metastatic disease Open
Statement Recurrence is very common in osteosarcoma, and the most common site of recurrence is in the lungs Open
Statement Recurrence is very common in osteosarcoma, and the most common site of recurrence is in the lungs Open
Quotation Extracellular vesicles or EVs are small nanoparticles released from all cells. Open
Quotation Extracellular vesicles or EVs are small nanoparticles released from all cells. Open
Statement Extracellular vesicles are carriers of amino acids, proteins, mRNA or other forms of cellular communication Open
Statement Extracellular vesicles are carriers of amino acids, proteins, mRNA or other forms of cellular communication Open
Statement EV content is unique and specific to the cells that released it, and therefore can be traced back to the cell type Open
Statement EV content is unique and specific to the cells that released it, and therefore can be traced back to the cell type Open
Statement EVs are involved in the metastatic cascade and implicated as potential markers for disease diagnosis and staging Open
Statement EVs are involved in the metastatic cascade and implicated as potential markers for disease diagnosis and staging Open
Statement EVs have been shown to change fibroblasts, inhibit T cell activity, and are involved in establishing a pre-metastatic niche Open
Statement EVs have been shown to change fibroblasts, inhibit T cell activity, and are involved in establishing a pre-metastatic niche Open
Quotation The aim of our study was to determine if extracellular vesicles from osteosarcoma can establish a pre-metastatic niche and increase pulmonary metastasis in a mirroring model of osteosarcoma. Open
Quotation The aim of our study was to determine if extracellular vesicles from osteosarcoma can establish a pre-metastatic niche and increase pulmonary metastasis in a mirroring model of osteosarcoma. Open
Statement K12 is a spontaneous osteosarcoma with low metastatic capability Open
Statement K12 is a spontaneous osteosarcoma with low metastatic capability Open
Statement K7M2 is a highly metastatic osteosarcoma derived from a spontaneous osteosarcoma that went through two reiterations of harvesting spontaneous lung metastases and reimplanting them into the mouse Open
Statement K7M2 is a highly metastatic osteosarcoma derived from a spontaneous osteosarcoma that went through two reiterations of harvesting spontaneous lung metastases and reimplanting them into the mouse Open
Statement The K7M2 cell line is more aggressive and causes death at a much higher rate than K12 Open
Statement The K7M2 cell line is more aggressive and causes death at a much higher rate than K12 Open
Statement Pre-education with K7M2 EVs drastically increases the metastatic burden in the lungs of mice with K7M2 tumors Open
Statement Pre-education with K7M2 EVs drastically increases the metastatic burden in the lungs of mice with K7M2 tumors Open
Statement Pre-education with K7M2 EVs increased the overall mortality during the five-week study period in mice with K7M2 tumors Open
Statement Pre-education with K7M2 EVs increased the overall mortality during the five-week study period in mice with K7M2 tumors Open
Statement K7M2 EV education led to increased metastatic burden in mice with K12 tumors Open
Statement K7M2 EV education led to increased metastatic burden in mice with K12 tumors Open
Statement Pre-education with highly metastatic cell line EVs increases the metastasis seen in a normally low metastatic tumor Open
Statement Pre-education with highly metastatic cell line EVs increases the metastasis seen in a normally low metastatic tumor Open
Statement No mice with K12 tumors died in the study period Open
Statement No mice with K12 tumors died in the study period Open
Statement Extracellular vesicles delivered prior to tumor implantation from highly metastatic K7M2 increase the metastatic burden of K7M2 tumors Open
Statement Extracellular vesicles delivered prior to tumor implantation from highly metastatic K7M2 increase the metastatic burden of K7M2 tumors Open
Statement Increased metastatic burden from extracellular vesicles decreases overall survival Open
Statement Increased metastatic burden from extracellular vesicles decreases overall survival Open
Statement Extracellular vesicles from highly metastatic K7M2 increase the metastatic burden of less metastatic K12 tumors Open
Statement Extracellular vesicles from highly metastatic K7M2 increase the metastatic burden of less metastatic K12 tumors Open
Quotation Extracellular vesicles can cause metastatic spread and therefore be a therapeutic target for osteosarcoma metastasis. Open
Quotation Extracellular vesicles can cause metastatic spread and therefore be a therapeutic target for osteosarcoma metastasis. Open
Statement All cells in the body release EVs, so we can't just generally target EVs and hope to decrease the establishment of a pre-metastatic niche Open
Statement All cells in the body release EVs, so we can't just generally target EVs and hope to decrease the establishment of a pre-metastatic niche Open
Statement IRF5 is a molecule being explored as a potential immunotherapy target in osteosarcoma EVs Open
Statement IRF5 is a molecule being explored as a potential immunotherapy target in osteosarcoma EVs Open
Quotation I don't think that it could treat the primary tumor as well as surgically removing it, which is, um, the current standard of care. Open
Quotation I don't think that it could treat the primary tumor as well as surgically removing it, which is, um, the current standard of care. Open
Statement Surgically removing the primary tumor is the current standard of care for osteosarcoma Open
Statement Surgically removing the primary tumor is the current standard of care for osteosarcoma Open
Statement There are certain membrane EV markers, but they're shared by all types of EVs Open
Statement There are certain membrane EV markers, but they're shared by all types of EVs Open
Statement The differences in EVs by cell type have more to do with the contents inside of them than the targets on them, which makes them difficult to target as far as treatment Open
Statement The differences in EVs by cell type have more to do with the contents inside of them than the targets on them, which makes them difficult to target as far as treatment Open
Statement Studies in dogs have shown ability to take serum of dogs with osteosarcoma and determine their likelihood of metastasis based on the EVs Open
Statement Studies in dogs have shown ability to take serum of dogs with osteosarcoma and determine their likelihood of metastasis based on the EVs Open
Bailey's statements about Sarcoma (Ewing/Rhabdo) 62 statements

Open the Sarcoma (Ewing/Rhabdo) collection →

Bailey Roberts, MD - Best of the Best in Pediatric Surgery 2024

Quotation Osteosarcoma is a malignant pediatric tumor of the bone. Open
Quotation Osteosarcoma is a malignant pediatric tumor of the bone. Open
Statement Osteosarcoma most commonly affects adolescents and young adults Open
Statement Osteosarcoma most commonly affects adolescents and young adults Open
Statement Gross metastasis at the time of diagnosis is present about 20% of the time in osteosarcoma Open
Statement The most common site of metastasis in osteosarcoma is in the lung Open
Statement Gross metastasis at the time of diagnosis is present about 20% of the time in osteosarcoma Open
Statement The most common site of metastasis in osteosarcoma is in the lung Open
Statement Overall survival in osteosarcoma worsens from 80% to about 20% for metastatic disease Open
Statement Overall survival in osteosarcoma worsens from 80% to about 20% for metastatic disease Open
Statement Recurrence is very common in osteosarcoma, and the most common site of recurrence is in the lungs Open
Statement Recurrence is very common in osteosarcoma, and the most common site of recurrence is in the lungs Open
Quotation Extracellular vesicles or EVs are small nanoparticles released from all cells. Open
Quotation Extracellular vesicles or EVs are small nanoparticles released from all cells. Open
Statement Extracellular vesicles are carriers of amino acids, proteins, mRNA or other forms of cellular communication Open
Statement Extracellular vesicles are carriers of amino acids, proteins, mRNA or other forms of cellular communication Open
Statement EV content is unique and specific to the cells that released it, and therefore can be traced back to the cell type Open
Statement EV content is unique and specific to the cells that released it, and therefore can be traced back to the cell type Open
Statement EVs are involved in the metastatic cascade and implicated as potential markers for disease diagnosis and staging Open
Statement EVs are involved in the metastatic cascade and implicated as potential markers for disease diagnosis and staging Open
Statement EVs have been shown to change fibroblasts, inhibit T cell activity, and are involved in establishing a pre-metastatic niche Open
Statement EVs have been shown to change fibroblasts, inhibit T cell activity, and are involved in establishing a pre-metastatic niche Open
Quotation The aim of our study was to determine if extracellular vesicles from osteosarcoma can establish a pre-metastatic niche and increase pulmonary metastasis in a mirroring model of osteosarcoma. Open
Quotation The aim of our study was to determine if extracellular vesicles from osteosarcoma can establish a pre-metastatic niche and increase pulmonary metastasis in a mirroring model of osteosarcoma. Open
Statement K12 is a spontaneous osteosarcoma with low metastatic capability Open
Statement K12 is a spontaneous osteosarcoma with low metastatic capability Open
Statement K7M2 is a highly metastatic osteosarcoma derived from a spontaneous osteosarcoma that went through two reiterations of harvesting spontaneous lung metastases and reimplanting them into the mouse Open
Statement K7M2 is a highly metastatic osteosarcoma derived from a spontaneous osteosarcoma that went through two reiterations of harvesting spontaneous lung metastases and reimplanting them into the mouse Open
Statement The K7M2 cell line is more aggressive and causes death at a much higher rate than K12 Open
Statement The K7M2 cell line is more aggressive and causes death at a much higher rate than K12 Open
Statement Pre-education with K7M2 EVs drastically increases the metastatic burden in the lungs of mice with K7M2 tumors Open
Statement Pre-education with K7M2 EVs drastically increases the metastatic burden in the lungs of mice with K7M2 tumors Open
Statement Pre-education with K7M2 EVs increased the overall mortality during the five-week study period in mice with K7M2 tumors Open
Statement Pre-education with K7M2 EVs increased the overall mortality during the five-week study period in mice with K7M2 tumors Open
Statement K7M2 EV education led to increased metastatic burden in mice with K12 tumors Open
Statement K7M2 EV education led to increased metastatic burden in mice with K12 tumors Open
Statement Pre-education with highly metastatic cell line EVs increases the metastasis seen in a normally low metastatic tumor Open
Statement Pre-education with highly metastatic cell line EVs increases the metastasis seen in a normally low metastatic tumor Open
Statement No mice with K12 tumors died in the study period Open
Statement No mice with K12 tumors died in the study period Open
Statement Extracellular vesicles delivered prior to tumor implantation from highly metastatic K7M2 increase the metastatic burden of K7M2 tumors Open
Statement Extracellular vesicles delivered prior to tumor implantation from highly metastatic K7M2 increase the metastatic burden of K7M2 tumors Open
Statement Increased metastatic burden from extracellular vesicles decreases overall survival Open
Statement Increased metastatic burden from extracellular vesicles decreases overall survival Open
Statement Extracellular vesicles from highly metastatic K7M2 increase the metastatic burden of less metastatic K12 tumors Open
Statement Extracellular vesicles from highly metastatic K7M2 increase the metastatic burden of less metastatic K12 tumors Open
Quotation Extracellular vesicles can cause metastatic spread and therefore be a therapeutic target for osteosarcoma metastasis. Open
Quotation Extracellular vesicles can cause metastatic spread and therefore be a therapeutic target for osteosarcoma metastasis. Open
Statement All cells in the body release EVs, so we can't just generally target EVs and hope to decrease the establishment of a pre-metastatic niche Open
Statement All cells in the body release EVs, so we can't just generally target EVs and hope to decrease the establishment of a pre-metastatic niche Open
Statement IRF5 is a molecule being explored as a potential immunotherapy target in osteosarcoma EVs Open
Statement IRF5 is a molecule being explored as a potential immunotherapy target in osteosarcoma EVs Open
Quotation I don't think that it could treat the primary tumor as well as surgically removing it, which is, um, the current standard of care. Open
Statement Surgically removing the primary tumor is the current standard of care for osteosarcoma Open
Quotation I don't think that it could treat the primary tumor as well as surgically removing it, which is, um, the current standard of care. Open
Statement Surgically removing the primary tumor is the current standard of care for osteosarcoma Open
Statement There are certain membrane EV markers, but they're shared by all types of EVs Open
Statement There are certain membrane EV markers, but they're shared by all types of EVs Open
Statement The differences in EVs by cell type have more to do with the contents inside of them than the targets on them, which makes them difficult to target as far as treatment Open
Statement The differences in EVs by cell type have more to do with the contents inside of them than the targets on them, which makes them difficult to target as far as treatment Open
Statement Studies in dogs have shown ability to take serum of dogs with osteosarcoma and determine their likelihood of metastasis based on the EVs Open
Statement Studies in dogs have shown ability to take serum of dogs with osteosarcoma and determine their likelihood of metastasis based on the EVs Open