Diana Mao

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Our compound of interest is oroonin, a diterpenoid that's derived from the plant species Rhabdosa rubiscens. This plant has been used for hundreds of years in eastern medicine to treat common ailments such as cough, abdominal pain, and muscle aches.
quote · Inflammatory Bowel Disease
In conclusion, we found that orodonin inhibits EMT-related fibrosis and does so via inhibition of the NF kappa B and P38 1 pathways. Consequently, oroonin may be a promising drug candidate for IBD and specifically within the context of fibrosis.
quote · Inflammatory Bowel Disease

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Diana's statements about Inflammatory Bowel Disease 31 statements

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Best of the Best Gen Surg - Therapeutic Effect of Oridonin against Inflammatory Bowel Disease Involves Inhibition of Intestinal Fibrosis via NF-kB and p38STAT1 Pathways - Dr. Mao

Quotation Intestinal fibrosis is a common sequela of IBD. It's found more frequently in Crohn's, affecting 30-50% of those patients, but it is also seen with ulcerative colitis, although less frequently at a rate of 5%. Open
Statement Inflammatory bowel disease affects approximately 3 million adults in the United States. Open
Statement The fibrosis process can lead to complications that present clinically in the form of strictures, obstruction, and fistulas. Open
Quotation So inflammatory bowel disease or IBD affects approximately 3 million adults in the United States, and it has significant costs for both patients and society. Open
Statement Intestinal fibrosis is seen with ulcerative colitis at a rate of 5%. Open
Statement Intestinal fibrosis affects 30-50% of Crohn's disease patients. Open
Statement The value of work-related opportunity lost due to IBD has been reported to be up to $5.5 billion. Open
Statement Annual medical expenses for a patient with IBD is estimated to be $15,000. Open
Statement During EMT, fibroblast markers such as alpha-SMA (alpha smooth muscle actin) and fibronectin are increasingly expressed. Open
Statement During EMT, epithelial markers such as E-cadherin and ZO-1 (zona occludens one) are lost. Open
Statement Epithelial-mesenchymal transition (EMT) is a process that contributes to the development of fibrosis, defined by the loss of adherences, tight junctions, and cytoskeleton proteins normally found in epithelial cells. Open
Statement Research has demonstrated that oridonin has antioxidant, anti-tumor, and anti-inflammatory effects on various tissues through inhibition of multiple signaling pathways including NF-κB and P38. Open
Quotation Our compound of interest is oroonin, a diterpenoid that's derived from the plant species Rhabdosa rubiscens. This plant has been used for hundreds of years in eastern medicine to treat common ailments such as cough, abdominal pain, and muscle aches. Open
Quotation We had two hypotheses with our study. First, we hypothesized that oroonin would attenuate inflammation-related EMT and fibrogenesis, and second, we hypothesized that this would occur through suppression of known pro-inflammatory pathways such as NF kappa B and P38. Open
Statement Oridonin is a diterpenoid derived from the plant species Rhabdosa rubiscens. Open
Statement Rhabdosa rubiscens has been used for hundreds of years in eastern medicine to treat common ailments such as cough, abdominal pain, and muscle aches. Open
Statement In studies with in vitro experiments and animal models, oridonin has resulted in slower IBD disease progression and decreased levels of inflammatory cytokines and cells. Open
Statement Oridonin inhibited LPS-induced fibrosis markers and restored ZO-1 expression in rat intestinal epithelial cells. Open
Statement Exposure to LPS decreased ZO-1 levels, and pre-treatment with oridonin was able to attenuate that effect and restore ZO-1 expression. Open
Statement Exposure to LPS increases fibronectin levels, but this effect was inhibited by pre-treatment with oridonin. Open
Statement Exposure to LPS increases levels of alpha-SMA, a marker of EMT and fibrosis, but this effect was inhibited by pre-treatment with oridonin. Open
Statement Oridonin inhibited the activation of NF-κB by preventing the nuclear translocation of NF-κB p65. Open
Statement NF-κB is a key pro-inflammatory pathway that regulates alpha-SMA. Open
Statement Oridonin inhibited the phosphorylation of IKK alpha-beta and I-κB alpha, and prevented total I-κB alpha degradation. Open
Statement The P38 inhibitor SB 203,580 dose-dependently attenuated LPS-induced alpha-SMA expression. Open
Statement Oridonin inhibits EMT-related fibrosis via inhibition of the NF-κB and P38/STAT1 pathways. Open
Quotation In conclusion, we found that orodonin inhibits EMT-related fibrosis and does so via inhibition of the NF kappa B and P38 1 pathways. Consequently, oroonin may be a promising drug candidate for IBD and specifically within the context of fibrosis. Open
Statement Oridonin inhibits LPS-induced STAT1 activity, which is a downstream factor of P38. Open
Quotation Yes, so it actually is derived from, you know, China. It's used a lot in their eastern medicine and has had therapeutic effects on common ailments and been used for 100. Hundreds of years. Open
Statement After breaking down the Rhabdosa rubiscens plant, researchers found that the most active compound was oridonin. Open
Statement Oridonin is derived from China and is used in eastern medicine, having been utilized for hundreds of years for common ailments. Open