Joe Palermo
89 statements · 5 topics · summaries given as host listed separately
Featured statements
In chronic pancreatitis, the presentation again can be a little bit variable, but what we want to see is that it's a combination of both their clinical presentation as well as their imaging findings, and we see that there should be some abnormal imaging findings that go along with what you're seeing clinically, usually ductal irregularities, calcifications, or pancreatic gland atrophy.
quote ·
Acute Recurrent Pancreatitis
Obviously if they're pancreatic exocrine insufficient and you put them on PET, they're bloating, their other GI symptoms may improve. A low fat diet is a healthier diet. Sometimes that is helpful with their symptoms as well, but there's no evidence that any of these interventions really prevent recurrent pancreatitis or pancreatic pain episodes.
quote ·
Acute Recurrent Pancreatitis
Unfortunately, the data doesn't hold true to that. So there have been multiple trials that have looked at a number of interventions to try and see if we can prevent recurrent pancreatitis episodes or pancreas pain episodes, and unfortunately, low fat diet, PETs, antioxidants, and steroids have never been shown to prevent those episodes.
quote ·
Pancreatitis
In adults where you see predominantly alcohol as the cause of chronic pancreatitis, with up to 70% of patients with chronic pancreatitis being caused by alcohol, the main risk factors for our patient population were were genetic, and then the second most common risk factor was an obstructive process or an anatomic process.
quote ·
Pancreatitis
until you really understand the true phenotype of the patient and their genotype, you're not going to be able to identify which patients are going to be able to be enrolled into a trial
quote ·
Acute Pancreatitis
Patients can certainly have acute recurrent pancreatitis and not have the evidence of ductile changes or pancreatic atrophy or pancreatic function loss.
quote ·
Chronic Pancreatitis
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Joe's statements about Acute Pancreatitis 14 statements
Open the Acute Pancreatitis collection →
Chronic Pancreatitis, Function Tests, & Pain Management: Pancreatic Disease
Statement
Between 7 and 34% of pediatric patients with acute pancreatitis will eventually develop recurrent episodes of pancreatitis
Open
Statement
Acute recurrent pancreatitis is defined as two distinct episodes of acute pancreatitis with either complete resolution between episodes or complete normalization of enzymes between episodes
Open
Statement
Chronic pancreatitis requires a combination of clinical presentation and abnormal imaging findings including ductal irregularities, calcifications, or pancreatic gland atrophy
Open
Quotation
patients can certainly have acute recurrent pancreatitis and not have the evidence of ductile changes or pancreatic atrophy or pancreatic function loss
Open
Statement
Patients can have acute recurrent pancreatitis without evidence of ductal changes, pancreatic atrophy, or pancreatic function loss
Open
Quotation
What leads them, tips them over the edge, what takes them from having acute recurrent pancreatitis to actually then developing chronic pancreatitis
Open
Quotation
in a 10-year-old who was previously healthy, this is, this is a very atypical finding
Open
Statement
In pediatric populations, the main risk factors for chronic pancreatitis are genetic, followed by obstructive or anatomic processes
Open
Statement
The CF Foundation has an extensive pipeline of small molecules to optimize CFTR function, particularly for atypical mutations
Open
Quotation
until you really understand the true phenotype of the patient and their genotype, you're not going to be able to identify which patients are going to be able to be enrolled into a trial
Open
Statement
Low fat diet, pancreatic enzyme replacement therapy, antioxidants, and steroids have never been shown to prevent recurrent pancreatitis episodes or pancreatic pain episodes
Open
Quotation
low fat diet, PETs, antioxidants, and steroids have never been shown to prevent those episodes
Open
Joe's statements about Acute Recurrent Pancreatitis 28 statements
Open the Acute Recurrent Pancreatitis collection →
Total Pancreatectomy with Islet Autotransplantation: Pancreatic Disease
Statement
TPIAT is indicated for chronic pain unresponsive to optimal medical and endoscopic approaches or surgical approaches and significantly impaired quality of life with repeated acute pancreatitis episodes, repeated admissions, missed school or work.
Open
Quotation
the main indication is chronic pain, unresponsive to optical, medical, and endoscopic approaches
Open
Chronic Pancreatitis, Function Tests, & Pain Management: Pancreatic Disease
Statement
Between 7 and 34% of pediatric patients with acute pancreatitis will eventually develop recurrent episodes.
Open
Quotation
Between 7 and 34% of pediatric patients will eventually develop recurrent episodes of pancreatitis.
Open
Statement
Acute recurrent pancreatitis is defined as two distinct episodes of acute pancreatitis with either complete resolution between episodes or complete normalization of enzymes between episodes.
Open
Quotation
The definition for acute recurrent pancreatitis is again two distinct episodes of acute pancreatitis with either complete resolution between episodes or complete normalization of enzymes between episodes.
Open
Statement
Chronic pancreatitis requires a combination of clinical presentation and abnormal imaging findings: ductal irregularities, calcifications, or pancreatic gland atrophy, seen on CT, MRCP, or ERCP.
Open
Quotation
In chronic pancreatitis, the presentation again can be a little bit variable, but what we want to see is that it's a combination of both their clinical presentation as well as their imaging findings, and we see that there should be some abnormal imaging findings that go along with what you're seeing clinically, usually ductal irregularities, calcifications, or pancreatic gland atrophy.
Open
Statement
Chronic pancreatitis diagnosis also requires abdominal pain consistent with pancreatic origin or evidence of endocrine or exocrine pancreatic insufficiency.
Open
Statement
Patients can have acute recurrent pancreatitis without evidence of ductal changes, pancreatic atrophy, or pancreatic function loss.
Open
Quotation
Patients can certainly have acute recurrent pancreatitis and not have the evidence of ductile changes or pancreatic atrophy or pancreatic function loss.
Open
Statement
Patients can have acute recurrent pancreatitis without evidence of ductal changes, pancreatic atrophy, or pancreatic function loss.
Open
Quotation
Patients can certainly have acute recurrent pancreatitis and not have the evidence of ductile changes or pancreatic atrophy or pancreatic function loss.
Open
Quotation
In adults where you see predominantly alcohol as the cause of chronic pancreatitis, with up to 70% of patients with chronic pancreatitis being caused by alcohol, the main risk factors for our patient population were were genetic, and then the second most common risk factor was an obstructive process or an anatomic process.
Open
Statement
In the pediatric cohort, the main risk factors for chronic pancreatitis were genetic, followed by obstructive or anatomic processes.
Open
Statement
In the pediatric cohort, the main risk factors for chronic pancreatitis were genetic, followed by obstructive or anatomic processes.
Open
Quotation
The CF Foundation actually has a very extensive pipeline of small molecules that they're using for patients that that optimize CFTR function. And so this is especially true for some of the atypical mutations.
Open
Statement
The CF Foundation has an extensive pipeline of small molecules optimizing CFTR function, which may offer therapeutic options for pancreatitis patients with CFTR mutations.
Open
Quotation
The CF Foundation actually has a very extensive pipeline of small molecules that they're using for patients that that optimize CFTR function. And so this is especially true for some of the atypical mutations.
Open
Statement
The CF Foundation has an extensive pipeline of small molecules optimizing CFTR function, which may offer therapeutic options for pancreatitis patients with CFTR mutations.
Open
Quotation
Unfortunately, the data doesn't hold true to that. So there have been multiple trials that have looked at a number of interventions to try and see if we can prevent recurrent pancreatitis episodes or pancreas pain episodes, and unfortunately, low fat diet, PETs, antioxidants, and steroids have never been shown to prevent those episodes.
Open
Statement
Low-fat diet, pancreatic enzyme replacement, antioxidants, and steroids have never been shown to prevent recurrent pancreatitis episodes or pancreatic pain episodes.
Open
Statement
Pancreatic enzyme replacement may improve bloating and other GI symptoms in patients with exocrine insufficiency, but does not prevent attacks.
Open
Quotation
Obviously if they're pancreatic exocrine insufficient and you put them on PET, they're bloating, their other GI symptoms may improve. A low fat diet is a healthier diet. Sometimes that is helpful with their symptoms as well, but there's no evidence that any of these interventions really prevent recurrent pancreatitis or pancreatic pain episodes.
Open
Statement
Pancreatic enzyme replacement may improve bloating and other GI symptoms in patients with exocrine insufficiency, but does not prevent attacks.
Open
Quotation
Obviously if they're pancreatic exocrine insufficient and you put them on PET, they're bloating, their other GI symptoms may improve. A low fat diet is a healthier diet. Sometimes that is helpful with their symptoms as well, but there's no evidence that any of these interventions really prevent recurrent pancreatitis or pancreatic pain episodes.
Open
Joe's statements about Chronic Pancreatitis 10 statements
Open the Chronic Pancreatitis collection →
Total Pancreatectomy with Islet Autotransplantation: Pancreatic Disease
Statement
TPIAT is indicated for chronic pain unresponsive to optimal medical and endoscopic approaches or surgical approaches and significantly impaired quality of life with repeated acute pancreatitis episodes, repeated admissions, missed school or work.
Open
Quotation
the main indication is chronic pain, unresponsive to optical, medical, and endoscopic approaches
Open
Chronic Pancreatitis, Function Tests, & Pain Management: Pancreatic Disease
Statement
Patients can have acute recurrent pancreatitis without evidence of ductal changes, pancreatic atrophy, or pancreatic function loss.
Open
Quotation
Patients can certainly have acute recurrent pancreatitis and not have the evidence of ductile changes or pancreatic atrophy or pancreatic function loss.
Open
Statement
In the pediatric cohort, the main risk factors for chronic pancreatitis were genetic, followed by obstructive or anatomic processes.
Open
Statement
The CF Foundation has an extensive pipeline of small molecules optimizing CFTR function, which may offer therapeutic options for pancreatitis patients with CFTR mutations.
Open
Quotation
The CF Foundation actually has a very extensive pipeline of small molecules that they're using for patients that that optimize CFTR function. And so this is especially true for some of the atypical mutations.
Open
Quotation
Obviously if they're pancreatic exocrine insufficient and you put them on PET, they're bloating, their other GI symptoms may improve. A low fat diet is a healthier diet. Sometimes that is helpful with their symptoms as well, but there's no evidence that any of these interventions really prevent recurrent pancreatitis or pancreatic pain episodes.
Open
Statement
Pancreatic enzyme replacement may improve bloating and other GI symptoms in patients with exocrine insufficiency, but does not prevent attacks.
Open
Joe's statements about Islet Cell / TPIAT 6 statements
Open the Islet Cell / TPIAT collection →
Total Pancreatectomy with Islet Autotransplantation: Pancreatic Disease
Quotation
the main indication is chronic pain, unresponsive to optical, medical, and endoscopic approaches
Open
Statement
TPIAT is indicated for chronic pain unresponsive to optimal medical and endoscopic approaches or surgical approaches and significantly impaired quality of life with repeated acute pancreatitis episodes, repeated admissions, missed school or work.
Open
Quotation
the main indication is chronic pain, unresponsive to optical, medical, and endoscopic approaches
Open
Statement
TPIAT is indicated for chronic pain unresponsive to optimal medical and endoscopic approaches or surgical approaches and significantly impaired quality of life with repeated acute pancreatitis episodes, repeated admissions, missed school or work.
Open
Joe's statements about Pancreatitis 31 statements
Open the Pancreatitis collection →
Total Pancreatectomy with Islet Autotransplantation: Pancreatic Disease
Quotation
the main indication is chronic pain, unresponsive to optical, medical, and endoscopic approaches
Open
Statement
TPIAT is indicated for chronic pain unresponsive to optimal medical and endoscopic approaches or surgical approaches and significantly impaired quality of life with repeated acute pancreatitis episodes, repeated admissions, missed school or work.
Open
Quotation
the main indication is chronic pain, unresponsive to optical, medical, and endoscopic approaches
Open
Statement
TPIAT is indicated for chronic pain unresponsive to optimal medical and endoscopic approaches or surgical approaches and significantly impaired quality of life with repeated acute pancreatitis episodes, repeated admissions, missed school or work.
Open
Chronic Pancreatitis, Function Tests, & Pain Management: Pancreatic Disease
Statement
Between 7 and 34% of pediatric patients with acute pancreatitis will eventually develop recurrent episodes.
Open
Quotation
Between 7 and 34% of pediatric patients will eventually develop recurrent episodes of pancreatitis.
Open
Statement
Acute recurrent pancreatitis is defined as two distinct episodes of acute pancreatitis with either complete resolution between episodes or complete normalization of enzymes between episodes.
Open
Quotation
The definition for acute recurrent pancreatitis is again two distinct episodes of acute pancreatitis with either complete resolution between episodes or complete normalization of enzymes between episodes.
Open
Quotation
In chronic pancreatitis, the presentation again can be a little bit variable, but what we want to see is that it's a combination of both their clinical presentation as well as their imaging findings, and we see that there should be some abnormal imaging findings that go along with what you're seeing clinically, usually ductal irregularities, calcifications, or pancreatic gland atrophy.
Open
Statement
Chronic pancreatitis requires a combination of clinical presentation and abnormal imaging findings: ductal irregularities, calcifications, or pancreatic gland atrophy, seen on CT, MRCP, or ERCP.
Open
Statement
Chronic pancreatitis diagnosis also requires abdominal pain consistent with pancreatic origin or evidence of endocrine or exocrine pancreatic insufficiency.
Open
Statement
Patients can have acute recurrent pancreatitis without evidence of ductal changes, pancreatic atrophy, or pancreatic function loss.
Open
Quotation
Patients can certainly have acute recurrent pancreatitis and not have the evidence of ductile changes or pancreatic atrophy or pancreatic function loss.
Open
Statement
Patients can have acute recurrent pancreatitis without evidence of ductal changes, pancreatic atrophy, or pancreatic function loss.
Open
Quotation
Patients can certainly have acute recurrent pancreatitis and not have the evidence of ductile changes or pancreatic atrophy or pancreatic function loss.
Open
Quotation
In adults where you see predominantly alcohol as the cause of chronic pancreatitis, with up to 70% of patients with chronic pancreatitis being caused by alcohol, the main risk factors for our patient population were were genetic, and then the second most common risk factor was an obstructive process or an anatomic process.
Open
Statement
In the pediatric cohort, the main risk factors for chronic pancreatitis were genetic, followed by obstructive or anatomic processes.
Open
Statement
In the pediatric cohort, the main risk factors for chronic pancreatitis were genetic, followed by obstructive or anatomic processes.
Open
Statement
The CF Foundation has an extensive pipeline of small molecules optimizing CFTR function, which may offer therapeutic options for pancreatitis patients with CFTR mutations.
Open
Quotation
The CF Foundation actually has a very extensive pipeline of small molecules that they're using for patients that that optimize CFTR function. And so this is especially true for some of the atypical mutations.
Open
Quotation
The CF Foundation actually has a very extensive pipeline of small molecules that they're using for patients that that optimize CFTR function. And so this is especially true for some of the atypical mutations.
Open
Statement
The CF Foundation has an extensive pipeline of small molecules optimizing CFTR function, which may offer therapeutic options for pancreatitis patients with CFTR mutations.
Open
Statement
Low-fat diet, pancreatic enzyme replacement, antioxidants, and steroids have never been shown to prevent recurrent pancreatitis episodes or pancreatic pain episodes.
Open
Quotation
Unfortunately, the data doesn't hold true to that. So there have been multiple trials that have looked at a number of interventions to try and see if we can prevent recurrent pancreatitis episodes or pancreas pain episodes, and unfortunately, low fat diet, PETs, antioxidants, and steroids have never been shown to prevent those episodes.
Open
Statement
Pancreatic enzyme replacement may improve bloating and other GI symptoms in patients with exocrine insufficiency, but does not prevent attacks.
Open
Quotation
Obviously if they're pancreatic exocrine insufficient and you put them on PET, they're bloating, their other GI symptoms may improve. A low fat diet is a healthier diet. Sometimes that is helpful with their symptoms as well, but there's no evidence that any of these interventions really prevent recurrent pancreatitis or pancreatic pain episodes.
Open
Statement
Pancreatic enzyme replacement may improve bloating and other GI symptoms in patients with exocrine insufficiency, but does not prevent attacks.
Open
Quotation
Obviously if they're pancreatic exocrine insufficient and you put them on PET, they're bloating, their other GI symptoms may improve. A low fat diet is a healthier diet. Sometimes that is helpful with their symptoms as well, but there's no evidence that any of these interventions really prevent recurrent pancreatitis or pancreatic pain episodes.
Open
Summaries Joe gave as host · 33 summaries
Recaps of other experts' statements, not Joe's own clinical position.
Summaries Joe gave as host · Acute Recurrent Pancreatitis 11 summaries
Open the Acute Recurrent Pancreatitis collection →
Chronic Pancreatitis, Function Tests, & Pain Management: Pancreatic Disease
Host summary
Joe Palermo summarizing the discussion: Between 7 and 34% of pediatric patients with acute pancreatitis will eventually develop recurrent episodes.
Open
Host summary
Joe Palermo summarizing the discussion: Between 7 and 34% of pediatric patients will eventually develop recurrent episodes of pancreatitis.
Open
Host summary
Joe Palermo summarizing the discussion: The definition for acute recurrent pancreatitis is again two distinct episodes of acute pancreatitis with either complete resolution between episodes or complete normalization of enzymes between episodes.
Open
Host summary
Joe Palermo summarizing the discussion: Acute recurrent pancreatitis is defined as two distinct episodes of acute pancreatitis with either complete resolution between episodes or complete normalization of enzymes between episodes.
Open
Host summary
Joe Palermo summarizing the discussion: Chronic pancreatitis requires a combination of clinical presentation and abnormal imaging findings: ductal irregularities, calcifications, or pancreatic gland atrophy, seen on CT, MRCP, or ERCP.
Open
Host summary
Joe Palermo summarizing the discussion: In chronic pancreatitis, the presentation again can be a little bit variable, but what we want to see is that it's a combination of both their clinical presentation as well as their imaging findings, and we see that there should be some abnormal imaging findings that go along with what you're seeing clinically, usually ductal irregularities, calcifications, or pancreatic gland atrophy.
Open
Host summary
Joe Palermo summarizing the discussion: Chronic pancreatitis diagnosis also requires abdominal pain consistent with pancreatic origin or evidence of endocrine or exocrine pancreatic insufficiency.
Open
Host summary
Joe Palermo summarizing the discussion: In adults where you see predominantly alcohol as the cause of chronic pancreatitis, with up to 70% of patients with chronic pancreatitis being caused by alcohol, the main risk factors for our patient population were were genetic, and then the second most common risk factor was an obstructive process or an anatomic process.
Open
Host summary
Joe Palermo summarizing the discussion: In adults, up to 70% of chronic pancreatitis cases are caused by alcohol.
Open
Host summary
Joe Palermo summarizing the discussion: Low-fat diet, pancreatic enzyme replacement, antioxidants, and steroids have never been shown to prevent recurrent pancreatitis episodes or pancreatic pain episodes.
Open
Host summary
Joe Palermo summarizing the discussion: Unfortunately, the data doesn't hold true to that. So there have been multiple trials that have looked at a number of interventions to try and see if we can prevent recurrent pancreatitis episodes or pancreas pain episodes, and unfortunately, low fat diet, PETs, antioxidants, and steroids have never been shown to prevent those episodes.
Open
Summaries Joe gave as host · Chronic Pancreatitis 11 summaries
Open the Chronic Pancreatitis collection →
Chronic Pancreatitis, Function Tests, & Pain Management: Pancreatic Disease
Host summary
Joe Palermo summarizing the discussion: Between 7 and 34% of pediatric patients will eventually develop recurrent episodes of pancreatitis.
Open
Host summary
Joe Palermo summarizing the discussion: Between 7 and 34% of pediatric patients with acute pancreatitis will eventually develop recurrent episodes.
Open
Host summary
Joe Palermo summarizing the discussion: The definition for acute recurrent pancreatitis is again two distinct episodes of acute pancreatitis with either complete resolution between episodes or complete normalization of enzymes between episodes.
Open
Host summary
Joe Palermo summarizing the discussion: Acute recurrent pancreatitis is defined as two distinct episodes of acute pancreatitis with either complete resolution between episodes or complete normalization of enzymes between episodes.
Open
Host summary
Joe Palermo summarizing the discussion: In chronic pancreatitis, the presentation again can be a little bit variable, but what we want to see is that it's a combination of both their clinical presentation as well as their imaging findings, and we see that there should be some abnormal imaging findings that go along with what you're seeing clinically, usually ductal irregularities, calcifications, or pancreatic gland atrophy.
Open
Host summary
Joe Palermo summarizing the discussion: Chronic pancreatitis requires a combination of clinical presentation and abnormal imaging findings: ductal irregularities, calcifications, or pancreatic gland atrophy, seen on CT, MRCP, or ERCP.
Open
Host summary
Joe Palermo summarizing the discussion: Chronic pancreatitis diagnosis also requires abdominal pain consistent with pancreatic origin or evidence of endocrine or exocrine pancreatic insufficiency.
Open
Host summary
Joe Palermo summarizing the discussion: In adults where you see predominantly alcohol as the cause of chronic pancreatitis, with up to 70% of patients with chronic pancreatitis being caused by alcohol, the main risk factors for our patient population were were genetic, and then the second most common risk factor was an obstructive process or an anatomic process.
Open
Host summary
Joe Palermo summarizing the discussion: In adults, up to 70% of chronic pancreatitis cases are caused by alcohol.
Open
Host summary
Joe Palermo summarizing the discussion: Low-fat diet, pancreatic enzyme replacement, antioxidants, and steroids have never been shown to prevent recurrent pancreatitis episodes or pancreatic pain episodes.
Open
Host summary
Joe Palermo summarizing the discussion: Unfortunately, the data doesn't hold true to that. So there have been multiple trials that have looked at a number of interventions to try and see if we can prevent recurrent pancreatitis episodes or pancreas pain episodes, and unfortunately, low fat diet, PETs, antioxidants, and steroids have never been shown to prevent those episodes.
Open
Summaries Joe gave as host · Pancreatitis 11 summaries
Open the Pancreatitis collection →
Chronic Pancreatitis, Function Tests, & Pain Management: Pancreatic Disease
Host summary
Joe Palermo summarizing the discussion: Between 7 and 34% of pediatric patients with acute pancreatitis will eventually develop recurrent episodes.
Open
Host summary
Joe Palermo summarizing the discussion: Between 7 and 34% of pediatric patients will eventually develop recurrent episodes of pancreatitis.
Open
Host summary
Joe Palermo summarizing the discussion: Acute recurrent pancreatitis is defined as two distinct episodes of acute pancreatitis with either complete resolution between episodes or complete normalization of enzymes between episodes.
Open
Host summary
Joe Palermo summarizing the discussion: The definition for acute recurrent pancreatitis is again two distinct episodes of acute pancreatitis with either complete resolution between episodes or complete normalization of enzymes between episodes.
Open
Host summary
Joe Palermo summarizing the discussion: In chronic pancreatitis, the presentation again can be a little bit variable, but what we want to see is that it's a combination of both their clinical presentation as well as their imaging findings, and we see that there should be some abnormal imaging findings that go along with what you're seeing clinically, usually ductal irregularities, calcifications, or pancreatic gland atrophy.
Open
Host summary
Joe Palermo summarizing the discussion: Chronic pancreatitis requires a combination of clinical presentation and abnormal imaging findings: ductal irregularities, calcifications, or pancreatic gland atrophy, seen on CT, MRCP, or ERCP.
Open
Host summary
Joe Palermo summarizing the discussion: Chronic pancreatitis diagnosis also requires abdominal pain consistent with pancreatic origin or evidence of endocrine or exocrine pancreatic insufficiency.
Open
Host summary
Joe Palermo summarizing the discussion: In adults where you see predominantly alcohol as the cause of chronic pancreatitis, with up to 70% of patients with chronic pancreatitis being caused by alcohol, the main risk factors for our patient population were were genetic, and then the second most common risk factor was an obstructive process or an anatomic process.
Open
Host summary
Joe Palermo summarizing the discussion: In adults, up to 70% of chronic pancreatitis cases are caused by alcohol.
Open
Host summary
Joe Palermo summarizing the discussion: Unfortunately, the data doesn't hold true to that. So there have been multiple trials that have looked at a number of interventions to try and see if we can prevent recurrent pancreatitis episodes or pancreas pain episodes, and unfortunately, low fat diet, PETs, antioxidants, and steroids have never been shown to prevent those episodes.
Open
Host summary
Joe Palermo summarizing the discussion: Low-fat diet, pancreatic enzyme replacement, antioxidants, and steroids have never been shown to prevent recurrent pancreatitis episodes or pancreatic pain episodes.
Open