Kasir Collaj

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One of the biggest challenges for babies with CDH is that fetal hypoplastic lungs are immature, whereby there is an impairment of cell differentiation, especially in the epithelium.
quote · Congenital Diaphragmatic Hernia
Congenital diaphragmatic hernia is characterized by impaired fetal lung growth and maturation. This condition has unacceptably high mortality and morbidity rates.
quote · Congenital Diaphragmatic Hernia

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Kasir's statements about Congenital Diaphragmatic Hernia 19 statements

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Quotation Congenital diaphragmatic hernia is characterized by impaired fetal lung growth and maturation. This condition has unacceptably high mortality and morbidity rates. Open
Statement Congenital diaphragmatic hernia is characterized by impaired fetal lung growth and maturation Open
Statement CDH has unacceptably high mortality and morbidity rates Open
Quotation One of the biggest challenges for babies with CDH is that fetal hypoplastic lungs are immature, whereby there is an impairment of cell differentiation, especially in the epithelium. Open
Statement One of the biggest challenges for babies with CDH is that fetal hypoplastic lungs are immature with impairment of cell differentiation, especially in the epithelium Open
Statement Extracellular vesicles (EVs) are the main mediators of stem cell paracrine signaling Open
Statement Amniotic fluid stem cell derived EVs can rescue fetal lung growth and maturation in several models of CDH at the pseudoglandular stage Open
Statement The pseudoglandular stage corresponds to 7 to 16 weeks of human gestation Open
Statement CDH is diagnosed around 18 to 20 weeks gestation Open
Statement The canalicular and saccular stages are translationally relevant developmental stages where intervention is possible for CDH Open
Statement The nitrophin model is a well-established model for studying CDH, created by administering the herbicide nitrophin to pregnant rat dams at embryonic day 9.5 Open
Statement Hypoplastic lungs at canalicular and saccular stages show down-regulation of alveolar type 1 and 2 cells, as well as basal and club cells compared to control Open
Quotation Remarkably, when we treat these hypoplastic lungs with the amniotic fluid stem cell derived extracellular vesicles, we are able to restore these primary markers, as you can see in the green shaded area, thus indicating that cell homeostasis can be achieved. Open
Statement Treatment of hypoplastic lungs with amniotic fluid stem cell derived extracellular vesicles restores primary markers of alveolar type 1 and 2 cells, basal cells, and club cells, indicating cell homeostasis can be achieved Open
Statement In vivo experiments have been performed looking at different administration routes including intraamniotic and tracheal routes for extracellular vesicles Open
Statement Results from in vivo administration of extracellular vesicles are quite promising Open
Statement Collaboration with Dr. Jan De Prest is underway to look at safety and feasibility of AFSC-EV treatment in a lab model Open
Statement The lack of ciliated cell rescue may be due to an imbalance of different cell types in the hypoplastic fetal lung, with the treatment achieving overall cell homeostatic balance rather than rescuing every specific cell type Open
Statement Key markers expressed in branching morphogenesis are being rescued effectively with AFSC-EV treatment Open