Maria Soledad Jara Valdivia

20 statements · 1 topic

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In conclusion, CD56 IHC stain is helpful as a complementary test in liver biopsies to rule out biliary atresia as an etiology for neonates presenting with cholestasis.

quote · Biliary Atresia

The immunohistochemical staining CD56 is useful in the diagnosis of biliary atresia.

quote · Biliary Atresia

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Maria's statements about Biliary Atresia 20 statements

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BOB Ped Surg 2023 - Maria Soledad Jara Valdivia, CIPESUR - Presentation

Statement Biliary atresia leads to liver cirrhosis without early treatment Open

Quotation The immunohistochemical staining CD56 is useful in the diagnosis of biliary atresia. Open

Statement The diagnosis of BA can be challenging as its histopathologic features overlap with those of other pediatric cholestatic liver diseases Open

Statement The most helpful hallmark of BA on histology is portal fibrosis and bile duct proliferation Open

Statement A similar pattern to BA can be found in other causes of cholestasis such as familiar intrahepatic cholestasis, neonatal hepatitis, and Alagille syndrome Open

Statement During cirrhosis, biliary epithelial structure express immunohistochemical markers of immaturity such as CD56 Open

Quotation CD56+ was defined as presence greater than 5% in the ductular epithelial cells. Open

Statement 639 biopsies were performed between 2013 and 2019 Open

Statement Final groups were distributed as: group BA equals 30 patients, group NC equals 28 patients, group C no BA equals 31 Open

Statement CD56 plus had sensitivity of 74% for BA versus 16% and 9% for other groups Open

Statement CD56 plus had specificity of 87.7% for BA versus 61% and 50% for other groups Open

Statement The PPV was 76% for BA versus 18% and 9% for other groups Open

Statement The NPV was 80% for BA versus 57% and 50% for other groups Open

Statement The AUC was 0.81 Open

Statement The labeling quantile from 6 to 25% had a higher sensitivity and adequate specificity Open

Statement CD56 in more than 5% of the ductular epithelial cells has a sensitivity of 74.2% versus 16.1% and 9.68% in non-BA groups Open

Statement CD56 has specificity of 87.7% and LHR+ of 6.04 compared to 0.42 and 0.20 in non BA group to diagnose biliary atresia Open

Statement An NPV of 86.2% shows that if CD56 is negative, biliary atresia is unlikely Open

Statement CD56 IHC stain is helpful as a complementary test in liver biopsies to rule out biliary atresia as an etiology for neonates presenting with cholestasis Open

Quotation In conclusion, CD56 IHC stain is helpful as a complementary test in liver biopsies to rule out biliary atresia as an etiology for neonates presenting with cholestasis. Open