Richard Wagner

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Prenatal diagnosis and prognostication of CDH cases relies currently only on imaging modalities, but sensitivity for CDH cases lies around 70% and remains imperfect in terms of family counseling and prognostication.

quote · Congenital Diaphragmatic Hernia

Circular RNAse is an RNA species with a circular shape that is highly stable in biofluids and again has potential as biomarkers in several human disease contexts.

quote · Congenital Diaphragmatic Hernia

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Richard's statements about Congenital Diaphragmatic Hernia 14 statements

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EUPSA - Circular RNA profiles isolated from amniotic fluidscan distinguish between CDH survivors and non-survivers - Richard Wagner

Statement Prenatal diagnosis and prognostication of CDH cases relies currently only on imaging modalities, with sensitivity around 70%. Open

Statement Circular RNAs are an RNA species with a circular shape that is highly stable in biofluids and has potential as biomarkers in several human disease contexts. Open

Statement Circular RNA profiles are significantly altered between CDH and control fetal lungs at two different developmental time points. Open

Statement An algorithm could cluster CDH lungs and control lungs into two separate groups based on circular RNA profiles at both investigated time points. Open

Statement At the time point of amniotic fluid sampling, observed over expected lung to head ratio was similar between CDH survivors and non-survivors. Open

Statement Gestational age, liver herniation, and birth weight did not differ between CDH survivor and non-survivor groups at the time of amniotic fluid sampling. Open

Statement Circular RNA profiles isolated from amniotic fluid samples can distinguish between CDH survivors and non-survivors, indicating prognostic value superior to current imaging modalities. Open

Quotation Circular RNAse is an RNA species with a circular shape that is highly stable in biofluids and again has potential as biomarkers in several human disease contexts. Open

Quotation It's important to say that at the time point of amniotic fluid sampling, there was no difference between the two groups. Observed over expected lung to head ratio was similar between survivors and non-survivors. Also, gestational age, liver herniation, or birth weight did not differ between the two groups. Open

Quotation Our goal is to validate these biomarkers in amniotic fluids in a larger and independent clinical cohort and define 2 to 3 markers that can predict outcomes in CDH cases, and also we want to test whether this marker can be isolated from maternal blood samples instead of amniotic fluid. This would make an ideal biomarker for prenatal CDH outcome prediction. Open

Quotation Prenatal diagnosis and prognostication of CDH cases relies currently only on imaging modalities, but sensitivity for CDH cases lies around 70% and remains imperfect in terms of family counseling and prognostication. Open

Statement The research team received funding from the Canadian Institutes of Health Research for a multi-center study to validate circular RNA biomarkers in CDH. Open

Statement The study is not currently powered to stratify syndromic CDH versus non-syndromic CDH cases or different severity levels. Open

Statement The investigators believe they have a disease-specific marker based on previous work with circular RNAs in CDH lungs. Open