Roshni Dasgupta

42 statements · 2 topics

Sarcoma (Ewing/Rhabdo) · guest expert

Featured statements

You will find about 30 to 40% more lung nodules with your fingers and looking than you actually find on CAT scan, even with our special MP scanning and our like thin cut CT scans.
quote · Osteosarcoma
About 40% of patients, you can get a. Durable cure response after 5 years. If you have complete metastatic site clearance, you can make these patients long-term survivors.
quote · Osteosarcoma
Our data actually from one of our PSA studies shows that even at the size of 1 millimeter, you can get about 60% of 1 millimeter nodules contained malignant disease.
quote · Sarcoma (Ewing/Rhabdo)
Most practitioners perform staged procedures for bilateral disease, particularly with thoracotomy, typically 4 to 6 weeks apart to allow a cycle of chemotherapy in between.
clinical · Sarcoma (Ewing/Rhabdo)

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Roshni's statements about Osteosarcoma 21 statements

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Update Course Rewind: Thoracotomy vs VATS for Lung Metastases

Quotation About 40% of patients, you can get a. Durable cure response after 5 years. If you have complete metastatic site clearance, you can make these patients long-term survivors. Open
Statement About 40% of patients can achieve a durable cure response after 5 years with complete metastatic site clearance. Open
Statement Complete surgical resection of all metastatic tumor sites is an independent positive prognostic factor and affects overall survival, not just disease recurrence. Open
Statement In patients with metastatic osteosarcoma, even 1-millimeter nodules can contain malignant disease in about 60% of cases. Open
Quotation Our data actually from one of our PSA studies shows that even at the size of 1 millimeter, you can get about 60% of 1 millimeter nodules contained malignant disease. Open
Statement The bigger the nodule is, the more likely it contains malignancy, but all the way down to 1 millimeter, tumor can be found. Open
Statement Thoracotomy has historically been standard of care because surgeons can use fingers and hands to feel tiny nodules. Open
Statement Manual palpation during thoracotomy finds about 30 to 40% more lung nodules than are detected on CT scan, even with thin-cut CT scans. Open
Quotation You will find about 30 to 40% more lung nodules with your fingers and looking than you actually find on CAT scan, even with our special MP scanning and our like thin cut CT scans. Open
Statement ICG can be used with thoracotomy to find deeper nodules, though depth of penetration is a limitation. Open
Statement It is uncertain whether removing tiny 1-millimeter nodules actually provides a survival advantage. Open
Statement VATS is minimally invasive with shorter length of stay, and repeat thoracoscopy typically encounters fewer adhesions compared to repeat thoracotomy. Open
Statement VATS often requires some sort of localization process and good interventional radiology support. Open
Statement In oligometastatic disease (patients with fewer than 4 nodules on each side), there was no difference in mortality between open resection and thoracoscopy. Open
Quotation Um, which really tells you that an oligometastatic disease, meaning that patients who have less than 4 nodules on each side, there was no difference in terms of mortality. Open
Statement The survival curves for thoracotomy and thoracoscopy in oligometastatic disease are essentially identical, meaning the optimal operation is unknown. Open
Quotation You know, sort of from a cancer surgeon perspective, you're like, I need to get all the tumor out all the time, but when you actually look at the data, maybe those small little nodules that you're feeling with a grain of sand don't actually make that much difference, and we don't know. Open
Statement The multi-institution study had significant selection bias and institutional selection bias, with patients unlikely to receive thoracoscopy if they had many nodules. Open
Statement Metastatic disease is typically addressed after 4 cycles of chemotherapy, and residual nodules at that point are unlikely to change with additional chemotherapy. Open
Statement Practice for bilateral lung metastases is highly varied, with options including median sternotomy, staged thoracotomies, or bilateral thoracoscopies. Open
Statement Most practitioners perform staged procedures for bilateral disease, particularly with thoracotomy, typically 4 to 6 weeks apart to allow a cycle of chemotherapy in between. Open
Roshni's statements about Sarcoma (Ewing/Rhabdo) 21 statements

Open the Sarcoma (Ewing/Rhabdo) collection →

Update Course Rewind: Thoracotomy vs VATS for Lung Metastases

Quotation About 40% of patients, you can get a. Durable cure response after 5 years. If you have complete metastatic site clearance, you can make these patients long-term survivors. Open
Statement About 40% of patients can achieve a durable cure response after 5 years with complete metastatic site clearance. Open
Statement Complete surgical resection of all metastatic tumor sites is an independent positive prognostic factor and affects overall survival, not just disease recurrence. Open
Quotation Our data actually from one of our PSA studies shows that even at the size of 1 millimeter, you can get about 60% of 1 millimeter nodules contained malignant disease. Open
Statement In patients with metastatic osteosarcoma, even 1-millimeter nodules can contain malignant disease in about 60% of cases. Open
Statement The bigger the nodule is, the more likely it contains malignancy, but all the way down to 1 millimeter, tumor can be found. Open
Statement Thoracotomy has historically been standard of care because surgeons can use fingers and hands to feel tiny nodules. Open
Quotation You will find about 30 to 40% more lung nodules with your fingers and looking than you actually find on CAT scan, even with our special MP scanning and our like thin cut CT scans. Open
Statement Manual palpation during thoracotomy finds about 30 to 40% more lung nodules than are detected on CT scan, even with thin-cut CT scans. Open
Statement ICG can be used with thoracotomy to find deeper nodules, though depth of penetration is a limitation. Open
Statement It is uncertain whether removing tiny 1-millimeter nodules actually provides a survival advantage. Open
Statement VATS is minimally invasive with shorter length of stay, and repeat thoracoscopy typically encounters fewer adhesions compared to repeat thoracotomy. Open
Statement VATS often requires some sort of localization process and good interventional radiology support. Open
Statement In oligometastatic disease (patients with fewer than 4 nodules on each side), there was no difference in mortality between open resection and thoracoscopy. Open
Quotation Um, which really tells you that an oligometastatic disease, meaning that patients who have less than 4 nodules on each side, there was no difference in terms of mortality. Open
Statement The survival curves for thoracotomy and thoracoscopy in oligometastatic disease are essentially identical, meaning the optimal operation is unknown. Open
Quotation You know, sort of from a cancer surgeon perspective, you're like, I need to get all the tumor out all the time, but when you actually look at the data, maybe those small little nodules that you're feeling with a grain of sand don't actually make that much difference, and we don't know. Open
Statement The multi-institution study had significant selection bias and institutional selection bias, with patients unlikely to receive thoracoscopy if they had many nodules. Open
Statement Metastatic disease is typically addressed after 4 cycles of chemotherapy, and residual nodules at that point are unlikely to change with additional chemotherapy. Open
Statement Practice for bilateral lung metastases is highly varied, with options including median sternotomy, staged thoracotomies, or bilateral thoracoscopies. Open
Statement Most practitioners perform staged procedures for bilateral disease, particularly with thoracotomy, typically 4 to 6 weeks apart to allow a cycle of chemotherapy in between. Open