Ryan Morgan
49 statements · 1 topic · summaries given as host listed separately
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When isolated in a germ-free mouse model, the high fat diet associated microbiome significantly increased the rate of post-operative tumor development.
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Colorectal / ARM & Hirschsprung
High-fat diet mice showed derangement of microbiome with overabundance of Alobaum and bloom of pathogenic bacteria such as Proteus, E. coli, and Shigella on postoperative day 7.
clinical ·
Colorectal / ARM & Hirschsprung
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Ryan's statements about Colorectal / ARM & Hirschsprung 49 statements
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Best of the Best Gen Surg - Development of postoperative local tumors and distant metastases in diet, genetics and microbiome-dependent in a mouse model of colorectal cancer recurrence - Dr. Morgan
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Traditional paradigms suggest recurrences are due to either incomplete resection or occult metastases left behind at the time of surgery.
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Colorectal cancer is a leading cause of cancer deaths, particularly in cases of recurrence.
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Colorectal cancer is a leading cause of cancer deaths, particularly in cases of recurrence.
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In the 1980s, UMLB showed that exfoliated cancer cells are present and viable at the time of surgery.
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When the primary colorectal tumor is resected, exfoliated cells remain behind within the lumen of the bowel and interact with the anastomotic microenvironment.
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When the primary colorectal tumor is resected, exfoliated cells remain behind within the lumen of the bowel and interact with the anastomotic microenvironment.
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Multiple factors can influence the anastomotic environment, including diet, the microbiome, and the tumor genetic background.
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Multiple factors can influence the anastomotic environment, including diet, the microbiome, and the tumor genetic background.
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We propose that the interaction of these factors in the healing anastomosis promotes the migration of these cells to cause both local and distant recurrences.
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We propose that the interaction of these factors in the healing anastomosis promotes the migration of these cells to cause both local and distant recurrences.
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our hypothesis is that a high fat diet and its impact on the microbiome would alter the anastomotic environment and change the metastatic potential of cells.
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A high-fat diet and its impact on the microbiome would alter the anastomotic environment and change the metastatic potential of cells.
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A high-fat diet and its impact on the microbiome would alter the anastomotic environment and change the metastatic potential of cells.
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our hypothesis is that a high fat diet and its impact on the microbiome would alter the anastomotic environment and change the metastatic potential of cells.
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AKPT and KPN organoid cell lines demonstrate a wide range of metastatic potential in animal models.
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AKPT mice showed significantly higher rate of tumor formation with a high-fat diet compared to mice given a chow diet by 56 days.
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AKPT mice showed significantly higher rate of tumor formation with a high-fat diet compared to mice given a chow diet by 56 days.
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KPN mice showed no significant difference in tumor formation based on diet, with an opposite trend towards higher rates in the chow diet.
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KPN mice showed no significant difference in tumor formation based on diet, with an opposite trend towards higher rates in the chow diet.
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AKPT mice given a high-fat diet had significantly decreased survival compared to those on a chow diet.
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AKPT mice given a high-fat diet had significantly decreased survival compared to those on a chow diet.
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KPN mice did not show any similar survival trend, suggesting that response to diet was at least in part based on the organoid genetic background.
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KPN mice did not show any similar survival trend, suggesting that response to diet was at least in part based on the organoid genetic background.
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When isolated in a germ-free mouse model, the high fat diet associated microbiome significantly increased the rate of post-operative tumor development.
Open
Quotation
When isolated in a germ-free mouse model, the high fat diet associated microbiome significantly increased the rate of post-operative tumor development.
Open
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In germ-free mice, the high-fat diet-associated microbiome significantly increased the rate of postoperative tumor development (40% vs 10-12% in control and chow FMT groups).
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In germ-free mice, the high-fat diet-associated microbiome significantly increased the rate of postoperative tumor development (40% vs 10-12% in control and chow FMT groups).
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Two-week diet reversal period was insufficient; mice in the reversal group continued to have poor survival and high tumor rates similar to the high-fat diet group.
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Two-week diet reversal period was insufficient; mice in the reversal group continued to have poor survival and high tumor rates similar to the high-fat diet group.
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Six-week diet reversal resulted in significantly increased survival and tumor rate similar to chow-fed mice, suggesting the response to diet and its reversal was time dependent.
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Six-week diet reversal resulted in significantly increased survival and tumor rate similar to chow-fed mice, suggesting the response to diet and its reversal was time dependent.
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High-fat diet mice showed derangement of microbiome with overabundance of Alobaum and bloom of pathogenic bacteria such as Proteus, E. coli, and Shigella on postoperative day 7.
Open
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High-fat diet mice showed derangement of microbiome with overabundance of Alobaum and bloom of pathogenic bacteria such as Proteus, E. coli, and Shigella on postoperative day 7.
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the reversal group very closely mirrors the composition of the child group, both in its baseline composition and in its response to surgery, suggesting that the reversal in phenotype we saw may be due to changes in the microbiome.
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The diet reversal group microbiome composition closely mirrored the chow group both in baseline composition and in response to surgery.
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The diet reversal group microbiome composition closely mirrored the chow group both in baseline composition and in response to surgery.
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the reversal group very closely mirrors the composition of the child group, both in its baseline composition and in its response to surgery, suggesting that the reversal in phenotype we saw may be due to changes in the microbiome.
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Preoperative diet manipulation reduces tumor formation, suggesting a clinically relevant role for diet rehabilitation in colorectal cancer treatment.
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with diet reversal experiments, we're able to show that preoperative diet manipulation reduces tumor formation by suggesting that there may be a clinically relevant role for diet rehabilitation and colorectal cancer treatment.
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with diet reversal experiments, we're able to show that preoperative diet manipulation reduces tumor formation by suggesting that there may be a clinically relevant role for diet rehabilitation and colorectal cancer treatment.
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Preoperative diet manipulation reduces tumor formation, suggesting a clinically relevant role for diet rehabilitation in colorectal cancer treatment.
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Combined mechanical and antibiotic bowel preparation preoperatively decreases rates of colorectal cancer recurrence.
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Preliminary in vitro data shows AKPT cells have more proliferative response to secondary bile acids (like deoxycholic acid) compared to KPN cells.
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Secondary bile acids and deoxycholic acid metabolites are exclusively bacterially produced.
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Secondary bile acids and deoxycholic acid metabolites are exclusively bacterially produced.
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Preliminary in vitro data shows AKPT cells have more proliferative response to secondary bile acids (like deoxycholic acid) compared to KPN cells.
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Summaries Ryan gave as host · 7 summaries
Recaps of other experts' statements, not Ryan's own clinical position.
Summaries Ryan gave as host · Colorectal / ARM & Hirschsprung 7 summaries
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Best of the Best Gen Surg - Development of postoperative local tumors and distant metastases in diet, genetics and microbiome-dependent in a mouse model of colorectal cancer recurrence - Dr. Morgan
Host summary
Ryan Morgan summarizing the discussion: Traditional paradigms suggest recurrences are due to either incomplete resection or occult metastases left behind at the time of surgery.
Open
Host summary
Ryan Morgan summarizing the discussion: Exfoliated cancer cells in the lumen of the bowel may be a source of recurrence.
Open
Host summary
Ryan Morgan summarizing the discussion: In the 1980s, UMLB showed that exfoliated cancer cells are present and viable at the time of surgery.
Open
Host summary
Ryan Morgan summarizing the discussion: Experimental cells could cross a watertight anastomosis in a mouse model.
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Host summary
Ryan Morgan summarizing the discussion: Rectal washout decreases rates of local recurrence after rectal cancer resection.
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Host summary
Ryan Morgan summarizing the discussion: AKPT and KPN organoid cell lines demonstrate a wide range of metastatic potential in animal models.
Open
Host summary
Ryan Morgan summarizing the discussion: Combined mechanical and antibiotic bowel preparation preoperatively decreases rates of colorectal cancer recurrence.
Open