Sophia Schermerhorn

259 statements · 8 topics

Liver Tumors (Hepatoblastoma/HCC) · guest expert Neuroblastoma · guest expert Sarcoma (Ewing/Rhabdo) · guest expert Single Ventricle / HLHS · episode host Soft Tissue Sarcoma (lymph nodes) · guest expert Wilms Tumor · episode host

Featured statements

This pattern suggests that solitary pulmonary relapse may represent a biologically more favorable type of recurrence, one that's more amenable to achieving meaningful local control, with metacystectomy playing an important role as part of multimodal therapy.
quote · Sarcoma (Ewing/Rhabdo)
The key takeaways long-term quality of life outcomes appear comparable between patients who undergo resection and liver transplantation. This means that the surgical strategy can really be focused on oncologic control.
quote · Hepatoblastoma
The presence of an IDRF doesn't mean that a tumor can't be resected, but it does signal that the surgery may be technically more complex, and patients often receive neoadjuvant therapy first to try to shrink the tumor.
quote · Neuroblastoma
The takeaway image-guided percutaneous biopsy is safe, accurate, and should be strongly considered the diagnostic modality of choice for pediatric bone and soft tissue tumors.
quote · Sarcoma (Ewing/Rhabdo)
Children who received cisplatin as part of their salvage therapy had a much better survival than those who did not, about 80% compared to 25%.
quote · Hepatoblastoma
If you're someone who treats neuroblastoma, you need to know about IDRFs to know whether it's safe to go to the operating room.
quote · Neuroblastoma

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Sophia's statements about Hepatoblastoma 41 statements

Open the Hepatoblastoma collection →

Early Postoperative Fever in Pediatric Oncology Patients Undergoing Solid Tumor Resection

Quotation Your patients post-op day one from a hepatoblastoma resection, and they spike a fever. Do you think they need a big fever workup? Open
Statement 42% of 220 oncology patients had a fever in the 48 hours following tumor resection Open
Statement The two patients with actual infection were hemodynamically unstable with positive blood cultures Open
Statement Only 2 of the febrile patients (2.8%) had an actual infection Open
Statement Most fevers triggered a workup that costs on average about $500 per patient Open
Statement About a third of patients received empiric antibiotics that they did not need Open
Quotation So here's the big takeaway. In the 48 hours following a tumor resection, a fever alone may not be a reason to panic. Open
Statement In the 48 hours following tumor resection, fever alone may not be a reason to panic Open
Statement Extensive workup should be reserved for patients who are hemodynamically unstable or have more overt signs of infection Open

Retreatment with Cisplatin May Provide a Survival Advantage for Children with Relapsed/Refractory Hepatoblastoma: An Institutional Experience

Quotation In relapse hepatoblastoma, there's no established standard salvage therapy regimen. Open
Statement There is no established standard salvage therapy regimen for relapsed hepatoblastoma Open
Statement The Cincinnati Children's retrospective review of 30 patients represents one of the largest published cohorts evaluating patients with refractory or recurrent hepatoblastoma Open
Statement The overall survival for the cohort was about 50% Open
Statement Children who received cisplatin as part of their salvage therapy had survival of about 80% compared to 25% for those who did not receive cisplatin Open
Quotation Children who received cisplatin as part of their salvage therapy had a much better survival than those who did not, about 80% compared to 25%. Open
Statement The improved survival outcomes with cisplatin may be due to persistent platinum sensitivity or better tumor biology rather than proving causality Open
Statement Most patients underwent additional surgery as part of their salvage therapy, either liver resection, liver transplant, or pulmonary metastasectomy Open
Statement Salvage therapy for relapsed hepatoblastoma is multimodal Open
Quotation This highlights that salvage therapy is multimodal. Open
Statement Cisplatin retreatment should be balanced with the risk of cumulative toxicity Open

Indocyanine green is a sensitive adjunct in the identification and surgical management of local and metastatic hepatoblastoma

Quotation Are you actually seeing all the hepatoblastoma during your resection? Open
Statement This is a single institution retrospective review of patients who received ICG prior to either pulmonary metastatectomy or liver resection for hepatoblastoma Open
Statement ICG was highly sensitive for detecting hepatoblastoma, about 90% Open
Statement In a meaningful number of cases, ICG was able to detect tumor deposits that were not visible, palpable, or detectable on preoperative imaging Open
Statement Specificity was lower than sensitivity with false positives Open
Statement False positives often represented vascular changes or inflammation Open
Statement There were no adverse outcomes associated with any of the additional resections guided by ICG Open
Statement ICG was effective in both open and minimally invasive surgery Open
Statement ICG was effective in both relapse and primary disease Open
Quotation ICG is a valuable tool that can help increase confidence in achieving a complete resection for both primary and metastatic hepatoblastoma. Open

Quality of Life Outcomes for Patients Who Underwent Conventional Resection and Liver Transplantation for Locally Advanced Hepatoblastoma

Statement Survival for hepatoblastoma continues to improve. Open
Statement Long-term quality of life is becoming a more important outcome as hepatoblastoma survival improves. Open
Statement This is a single institution cross-sectional study using validated pediatric quality of life surveys to evaluate long-term survivors of hepatoblastoma. Open
Statement Overall quality of life outcomes were similar between liver transplant and resection groups for hepatoblastoma. Open
Statement There was no significant difference in emotional, social, physical, or school functioning outcomes between transplant and resection groups. Open
Quotation This challenges the assumption that liver transplantation necessarily leads to a worse. Long-term quality of life. Open
Statement Patients who underwent resection had lower overall procedure anxiety scores than transplant patients. Open
Statement The finding of lower procedural anxiety in resection patients was mirrored in the parents' surveys. Open
Statement Long-term quality of life outcomes appear comparable between patients who undergo resection and liver transplantation for hepatoblastoma. Open
Quotation The key takeaways long-term quality of life outcomes appear comparable between patients who undergo resection and liver transplantation. This means that the surgical strategy can really be focused on oncologic control. Open
Statement Surgical strategy for hepatoblastoma can be focused on oncologic control given comparable quality of life outcomes. Open
Sophia's statements about High-risk Neuroblastoma 15 statements

Open the High-risk Neuroblastoma collection →

Pancreas, Muscle, and Subcutaneous Fat Atrophy in Patients Undergoing Radiation for Neuroblastoma

Quotation So, we know radiation improves survival in high-risk neuroblastoma, but what does it do to the rest of the body? Open
Statement Radiation improves survival in high-risk neuroblastoma Open
Statement This is a retrospective study of 50 children with high-risk neuroblastoma undergoing abdominal radiation therapy Open
Statement The authors use CT and MRI body segmentation to measure pancreatic volume, subcutaneous fat, and muscle area before and after treatment Open
Statement There was a significant decrease in pancreatic volume after radiation Open
Statement Very few patients developed clinically apparent pancreatic insufficiency Open
Statement Pancreatic insufficiency wasn't systematically screened for in this study Open
Statement Follow-up may not be long enough to detect pancreatic effects, especially given the young average age of these patients Open
Quotation So this raises concern that pancreatic dysfunction could be an Recognized late effect. Open
Statement Pancreatic dysfunction could be an under-recognized late effect Open
Statement Body composition changes likely reflect the overall impact of cancer therapy overall rather than radiation alone Open
Statement These findings highlight the importance of nutritional screening during cancer treatments Open
Statement Patients had a significant drop in weight percentile with smaller decreases in fat and muscle Open
Statement As survival improves, understanding and screening for long-term effects is becoming just as important as curing the cancer itself Open
Quotation So, as survival improves, understanding and screening for these long-term effects is becoming just as important as curing the cancer itself. Open
Sophia's statements about Liver Tumors (Hepatoblastoma/HCC) 42 statements

Open the Liver Tumors (Hepatoblastoma/HCC) collection →

Social Determinants of Health Influence on Survival in Wilms Tumor, Neuroblastoma, and Hepatoblastoma

Quotation How much does a child's social factors influence their chance of surviving cancer? Open
Statement Study was a retrospective analysis of 12,000 patients with neuroblastoma, Wilms tumor, and hepatoblastoma from the National Cancer Database Open
Statement Socioeconomic disadvantage score was created for each patient based on median household income and education level in their local communities Open
Statement The most disadvantaged children were more likely to have worse survival for Wilms tumor and neuroblastoma Open
Statement After adjusting for tumor size, grade, treatment, and comorbidities, socioeconomic effects on survival remained present Open
Statement Hazard ratio for socioeconomic disadvantage was 2.02 for Wilms tumor Open
Statement Hazard ratio for socioeconomic disadvantage was 1.29 for hepatoblastoma Open
Statement Pediatric oncology outcomes depend on tumor biology, treatment received, and social determinants of health Open
Quotation Pediatric oncology outcomes aren't just about tumor biology or treatment received. It's about the social determinants of health for these children as well. Open
Statement Identifying socioeconomic risk factors is necessary to close equity gaps and improve survival for all children with solid tumors Open

Retreatment with Cisplatin May Provide a Survival Advantage for Children with Relapsed/Refractory Hepatoblastoma: An Institutional Experience

Quotation In relapse hepatoblastoma, there's no established standard salvage therapy regimen. Open
Statement There is no established standard salvage therapy regimen for relapsed hepatoblastoma Open
Statement The Cincinnati Children's retrospective review of 30 patients represents one of the largest published cohorts evaluating patients with refractory or recurrent hepatoblastoma Open
Statement The overall survival for the cohort was about 50% Open
Statement Children who received cisplatin as part of their salvage therapy had survival of about 80% compared to 25% for those who did not receive cisplatin Open
Quotation Children who received cisplatin as part of their salvage therapy had a much better survival than those who did not, about 80% compared to 25%. Open
Statement The improved survival outcomes with cisplatin may be due to persistent platinum sensitivity or better tumor biology rather than proving causality Open
Statement Most patients underwent additional surgery as part of their salvage therapy, either liver resection, liver transplant, or pulmonary metastasectomy Open
Quotation This highlights that salvage therapy is multimodal. Open
Statement Salvage therapy for relapsed hepatoblastoma is multimodal Open
Statement Cisplatin retreatment should be balanced with the risk of cumulative toxicity Open

Indocyanine green is a sensitive adjunct in the identification and surgical management of local and metastatic hepatoblastoma

Quotation Are you actually seeing all the hepatoblastoma during your resection? Open
Statement This is a single institution retrospective review of patients who received ICG prior to either pulmonary metastatectomy or liver resection for hepatoblastoma Open
Statement ICG was highly sensitive for detecting hepatoblastoma, about 90% Open
Statement In a meaningful number of cases, ICG was able to detect tumor deposits that were not visible, palpable, or detectable on preoperative imaging Open
Statement Specificity was lower than sensitivity with false positives Open
Statement False positives often represented vascular changes or inflammation Open
Statement There were no adverse outcomes associated with any of the additional resections guided by ICG Open
Statement ICG was effective in both open and minimally invasive surgery Open
Statement ICG was effective in both relapse and primary disease Open
Quotation ICG is a valuable tool that can help increase confidence in achieving a complete resection for both primary and metastatic hepatoblastoma. Open

Quality of Life Outcomes for Patients Who Underwent Conventional Resection and Liver Transplantation for Locally Advanced Hepatoblastoma

Statement Long-term quality of life is becoming a more important outcome as hepatoblastoma survival improves. Open
Statement Survival for hepatoblastoma continues to improve. Open
Statement This is a single institution cross-sectional study using validated pediatric quality of life surveys to evaluate long-term survivors of hepatoblastoma. Open
Statement There was no significant difference in emotional, social, physical, or school functioning outcomes between transplant and resection groups. Open
Statement Overall quality of life outcomes were similar between liver transplant and resection groups for hepatoblastoma. Open
Quotation This challenges the assumption that liver transplantation necessarily leads to a worse. Long-term quality of life. Open
Statement Patients who underwent resection had lower overall procedure anxiety scores than transplant patients. Open
Statement The finding of lower procedural anxiety in resection patients was mirrored in the parents' surveys. Open
Statement Long-term quality of life outcomes appear comparable between patients who undergo resection and liver transplantation for hepatoblastoma. Open
Quotation The key takeaways long-term quality of life outcomes appear comparable between patients who undergo resection and liver transplantation. This means that the surgical strategy can really be focused on oncologic control. Open
Statement Surgical strategy for hepatoblastoma can be focused on oncologic control given comparable quality of life outcomes. Open
Sophia's statements about Neuroblastoma 63 statements

Open the Neuroblastoma collection →

Social Determinants of Health Influence on Survival in Wilms Tumor, Neuroblastoma, and Hepatoblastoma

Quotation How much does a child's social factors influence their chance of surviving cancer? Open
Statement Study was a retrospective analysis of 12,000 patients with neuroblastoma, Wilms tumor, and hepatoblastoma from the National Cancer Database Open
Statement Socioeconomic disadvantage score was created for each patient based on median household income and education level in their local communities Open
Statement The most disadvantaged children were more likely to have worse survival for Wilms tumor and neuroblastoma Open
Statement After adjusting for tumor size, grade, treatment, and comorbidities, socioeconomic effects on survival remained present Open
Statement Hazard ratio for socioeconomic disadvantage was 2.02 for Wilms tumor Open
Statement Hazard ratio for socioeconomic disadvantage was 1.29 for hepatoblastoma Open
Statement Pediatric oncology outcomes depend on tumor biology, treatment received, and social determinants of health Open
Quotation Pediatric oncology outcomes aren't just about tumor biology or treatment received. It's about the social determinants of health for these children as well. Open
Statement Identifying socioeconomic risk factors is necessary to close equity gaps and improve survival for all children with solid tumors Open

Enhanced Recovery After Surgery (ERAS) Improves Length of Stay and Decreases Complications After Resection of Abdominal Neuroblastoma

Quotation Did you know there's an ERAS protocol for neuroblastoma? Open
Statement A multi-center prospective study evaluated a structured ERAS pathway for children undergoing abdominal neuroblastoma resection Open
Statement ERAS protocol elements included preoperative counseling, hydrate loading, standardized multimodal analgesia, early feeding, and early mobilization Open
Statement The ERAS protocol included 20 evidence-based elements spanning the entire perioperative process Open
Quotation The results were striking. Open
Statement Length of stay decreased from about 7 days to 3.7 days Open
Statement Post-operative opioid use dropped by over half Open
Statement Patients resumed regular diets and ambulated about 3 days earlier Open
Statement The proportion of patients experiencing any postoperative complication decreased by over 50% Open
Statement Patients were cleared to resume adjuvant chemotherapy earlier at around 8 days as opposed to 10 days Open
Statement A structured ERAS pathway meaningfully improves recovery even after complex neuroblastoma resections Open
Statement ERAS represents a tangible opportunity to standardize perioperative care for neuroblastoma resection Open

Long-Term Follow-Up of Surgical Outcomes for Patients With Wilms Tumor and Neuroblastoma

Quotation You just surgically treated your patient with Wilms tumor or neuroblastoma. Now what? Open
Statement This single institution cohort followed survivors for a mean of 27 years after open oncologic resection for Wilms tumor and neuroblastoma Open
Statement 14% of patients required a repeat laparotomy Open
Statement The most common indications for repeat laparotomy were small bowel obstruction or tumor recurrence Open
Statement In Wilms tumor, obstruction typically occurred within the first year Open
Statement In neuroblastoma, obstruction often developed more than a decade later, well beyond routine follow-up Open
Statement Radiation dose was not associated with re-operation risk Open
Statement Secondary malignancy was uncommon in this cohort Open
Statement Hypertension after nephrectomy was not increased compared to population norms Open
Statement Scoliosis occurred in roughly 10 to 13% of patients, higher than the general population Open
Statement Scoliosis has multi-factorial contributors including surgery and possibly radiation Open
Quotation The takeaway is that surgical care does not end at resection. Open
Statement Even decades after treatment, these patients remain at risk for late complications that warrant long-term counseling and follow-up Open

The International Neuroblastoma Risk Group (INRG) staging system: an INRG Task Force report

Statement IDRFs are necessary knowledge for clinicians treating neuroblastoma to determine safety of surgical intervention Open
Quotation If you're someone who treats neuroblastoma, you need to know about IDRFs to know whether it's safe to go to the operating room. Open
Statement IDRFs are imaging findings on CT or MRI that predict when neuroblastoma may be difficult or dangerous to remove surgically Open
Quotation IDRFs are imaging findings on CT or MRIs that predict when a neuroblastoma may be difficult or dangerous to remove surgically. Open
Statement The International Neuroblastoma Risk Group defined 20 specific imaging risk factors Open
Statement The IDRF concept was first introduced in 2009 by the International Neuroblastoma Risk Group Open
Statement Most IDRFs relate to how the tumor interacts with critical anatomy Open
Statement In the abdomen, a tumor that infiltrates the portahepati or hepatoduodenal ligament is considered to contain an IDRF Open
Statement IDRF presence signals that surgery may be technically more complex Open
Quotation The presence of an IDRF doesn't mean that a tumor can't be resected, but it does signal that the surgery may be technically more complex, and patients often receive neoadjuvant therapy first to try to shrink the tumor. Open
Statement The presence of an IDRF does not mean a tumor cannot be resected Open
Statement Patients with IDRFs often receive neoadjuvant therapy first to try to shrink the tumor Open
Statement Surgeons use IDRFs to predict surgical risk and guide the safest treatment approach using imaging Open

Pancreas, Muscle, and Subcutaneous Fat Atrophy in Patients Undergoing Radiation for Neuroblastoma

Quotation So, we know radiation improves survival in high-risk neuroblastoma, but what does it do to the rest of the body? Open
Statement Radiation improves survival in high-risk neuroblastoma Open
Statement This is a retrospective study of 50 children with high-risk neuroblastoma undergoing abdominal radiation therapy Open
Statement The authors use CT and MRI body segmentation to measure pancreatic volume, subcutaneous fat, and muscle area before and after treatment Open
Statement There was a significant decrease in pancreatic volume after radiation Open
Statement Follow-up may not be long enough to detect pancreatic effects, especially given the young average age of these patients Open
Statement Very few patients developed clinically apparent pancreatic insufficiency Open
Statement Pancreatic insufficiency wasn't systematically screened for in this study Open
Quotation So this raises concern that pancreatic dysfunction could be an Recognized late effect. Open
Statement Pancreatic dysfunction could be an under-recognized late effect Open
Statement Body composition changes likely reflect the overall impact of cancer therapy overall rather than radiation alone Open
Statement Patients had a significant drop in weight percentile with smaller decreases in fat and muscle Open
Statement These findings highlight the importance of nutritional screening during cancer treatments Open
Quotation So, as survival improves, understanding and screening for these long-term effects is becoming just as important as curing the cancer itself. Open
Statement As survival improves, understanding and screening for long-term effects is becoming just as important as curing the cancer itself Open
Sophia's statements about Sarcoma (Ewing/Rhabdo) 48 statements

Open the Sarcoma (Ewing/Rhabdo) collection →

Current management of pulmonary relapse in Ewing sarcoma: A report from the Pediatric Surgical Oncology Research Collaborative

Statement Writer et al. published a multi-center retrospective study in the Journal of Pediatric Surgery through PeaceSOC in 2024 Open
Statement PeaceSOC is a network of over 50 centers in North America that work together to improve outcomes in pediatric surgical oncology Open
Statement The study examined patients less than 22 years old with initially localized Ewing sarcoma who developed first pulmonary relapse between 2007 and 2020 across 19 different centers Open
Statement Among 33 patients studied, about 2/3 had relapse limited to the lungs Open
Statement Nearly half of patients with lung-limited relapse had just a solitary pulmonary nodule Open
Statement Patients with solitary pulmonary nodule were more likely to undergo metastasectomy and whole lung radiation Open
Statement Patients with solitary pulmonary nodule had the highest overall three-year survival at 73% Open
Statement Three-year survival for patients with multiple nodules was 40% Open
Statement Three-year survival for patients with extrapulmonary disease was 23% Open
Statement Solitary pulmonary relapse is more amenable to achieving meaningful local control Open
Quotation This pattern suggests that solitary pulmonary relapse may represent a biologically more favorable type of recurrence, one that's more amenable to achieving meaningful local control, with metacystectomy playing an important role as part of multimodal therapy. Open
Statement Metastasectomy plays an important role as part of multimodal therapy for solitary pulmonary relapse in Ewing sarcoma Open
Statement Solitary pulmonary relapse may represent a biologically more favorable type of recurrence Open

Early Postoperative Fever in Pediatric Oncology Patients Undergoing Solid Tumor Resection

Quotation Your patients post-op day one from a hepatoblastoma resection, and they spike a fever. Do you think they need a big fever workup? Open
Statement 42% of 220 oncology patients had a fever in the 48 hours following tumor resection Open
Statement The two patients with actual infection were hemodynamically unstable with positive blood cultures Open
Statement Only 2 of the febrile patients (2.8%) had an actual infection Open
Statement Most fevers triggered a workup that costs on average about $500 per patient Open
Statement About a third of patients received empiric antibiotics that they did not need Open
Quotation So here's the big takeaway. In the 48 hours following a tumor resection, a fever alone may not be a reason to panic. Open
Statement In the 48 hours following tumor resection, fever alone may not be a reason to panic Open
Statement Extensive workup should be reserved for patients who are hemodynamically unstable or have more overt signs of infection Open

Pediatric and Young Adult Image-Guided Percutaneous Bone Biopsy-A New Standard of Care?

Quotation Are you still doing open biopsy for pediatric bone tumors? Open
Statement The study evaluated 169 biopsies in 141 patients over a 10-year period at a single institution. Open
Statement Nearly 90% of the biopsies were core-needle biopsies. Open
Statement All biopsies were performed with image guidance, most commonly CT, sometimes combined with fluoroscopy and ultrasound. Open
Statement All biopsies were performed by interventional radiologists. Open
Quotation The diagnostic yield was impressive. Open
Statement Only 3 patients required repeat biopsy. Open
Statement 97.9% of biopsies were diagnostic. Open
Statement There was one patient with transient sciatic nerve paresis, which resolved. Open
Statement The complication rate was 0.7%. Open
Statement Immunostains and molecular studies are increasingly essential for modern risk stratification and targeted therapy. Open
Statement The approach provided sufficient tissue for histology, immunostains, and molecular studies. Open
Statement Image-guided percutaneous biopsy should be strongly considered the diagnostic modality of choice for pediatric bone and soft tissue tumors. Open
Quotation The takeaway image-guided percutaneous biopsy is safe, accurate, and should be strongly considered the diagnostic modality of choice for pediatric bone and soft tissue tumors. Open

Indocyanine green assists with sentinel lymph node mapping in pediatric and adolescent patients

Quotation So just how accurate is ICG for detecting sentinel lymph nodes in pediatric oncology? Open
Statement The study was a multi-center prospective study conducted by PeaceOC evaluating indocyanine green (ICG) for identifying sentinel lymph nodes in pediatric patients with skin and soft tissue malignancies Open
Statement Peritumoral injection of ICG demonstrated almost 80% sensitivity for detecting a sentinel node Open
Quotation all sentinel nodes that contained malignancy were ICG avid Open
Statement All sentinel nodes that contained malignancy were ICG avid Open
Statement ICG diagnostic performance is similar to smaller pediatric studies previously evaluating ICG and sentinel lymph node biopsy Open
Statement ICG may outperform blue dye localization based on previously reported literature Open
Statement The study did not directly compare the effectiveness of ICG to blue dye localization Open
Statement ICG in most cases was used in conjunction with standard localization techniques such as technetium Open
Statement No adverse reactions to ICG were identified within 30 days of surgery Open
Statement ICG has a favorable safety profile and lacks the permanent tattooing associated with blue dye, making it an attractive visualization adjunct for pediatric sentinel lymph node biopsy Open
Statement Blue dye can cause permanent tattooing Open
Sophia's statements about Single Ventricle / HLHS 15 statements

Open the Single Ventricle / HLHS collection →

Pancreas, Muscle, and Subcutaneous Fat Atrophy in Patients Undergoing Radiation for Neuroblastoma

Quotation So, we know radiation improves survival in high-risk neuroblastoma, but what does it do to the rest of the body? Open
Statement Radiation improves survival in high-risk neuroblastoma Open
Statement This is a retrospective study of 50 children with high-risk neuroblastoma undergoing abdominal radiation therapy Open
Statement The authors use CT and MRI body segmentation to measure pancreatic volume, subcutaneous fat, and muscle area before and after treatment Open
Statement There was a significant decrease in pancreatic volume after radiation Open
Statement Very few patients developed clinically apparent pancreatic insufficiency Open
Statement Pancreatic insufficiency wasn't systematically screened for in this study Open
Statement Follow-up may not be long enough to detect pancreatic effects, especially given the young average age of these patients Open
Quotation So this raises concern that pancreatic dysfunction could be an Recognized late effect. Open
Statement Pancreatic dysfunction could be an under-recognized late effect Open
Statement Body composition changes likely reflect the overall impact of cancer therapy overall rather than radiation alone Open
Statement Patients had a significant drop in weight percentile with smaller decreases in fat and muscle Open
Statement These findings highlight the importance of nutritional screening during cancer treatments Open
Quotation So, as survival improves, understanding and screening for these long-term effects is becoming just as important as curing the cancer itself. Open
Statement As survival improves, understanding and screening for long-term effects is becoming just as important as curing the cancer itself Open
Sophia's statements about Soft Tissue Sarcoma (lymph nodes) 12 statements

Open the Soft Tissue Sarcoma (lymph nodes) collection →

Indocyanine green assists with sentinel lymph node mapping in pediatric and adolescent patients

Quotation So just how accurate is ICG for detecting sentinel lymph nodes in pediatric oncology? Open
Statement The study was a multi-center prospective study conducted by PeaceOC evaluating indocyanine green (ICG) for identifying sentinel lymph nodes in pediatric patients with skin and soft tissue malignancies Open
Statement Peritumoral injection of ICG demonstrated almost 80% sensitivity for detecting a sentinel node Open
Statement All sentinel nodes that contained malignancy were ICG avid Open
Quotation all sentinel nodes that contained malignancy were ICG avid Open
Statement ICG diagnostic performance is similar to smaller pediatric studies previously evaluating ICG and sentinel lymph node biopsy Open
Statement ICG may outperform blue dye localization based on previously reported literature Open
Statement The study did not directly compare the effectiveness of ICG to blue dye localization Open
Statement ICG in most cases was used in conjunction with standard localization techniques such as technetium Open
Statement No adverse reactions to ICG were identified within 30 days of surgery Open
Statement ICG has a favorable safety profile and lacks the permanent tattooing associated with blue dye, making it an attractive visualization adjunct for pediatric sentinel lymph node biopsy Open
Statement Blue dye can cause permanent tattooing Open
Sophia's statements about Wilms Tumor 23 statements

Open the Wilms Tumor collection →

Social Determinants of Health Influence on Survival in Wilms Tumor, Neuroblastoma, and Hepatoblastoma

Quotation How much does a child's social factors influence their chance of surviving cancer? Open
Statement Study was a retrospective analysis of 12,000 patients with neuroblastoma, Wilms tumor, and hepatoblastoma from the National Cancer Database Open
Statement Socioeconomic disadvantage score was created for each patient based on median household income and education level in their local communities Open
Statement The most disadvantaged children were more likely to have worse survival for Wilms tumor and neuroblastoma Open
Statement After adjusting for tumor size, grade, treatment, and comorbidities, socioeconomic effects on survival remained present Open
Statement Hazard ratio for socioeconomic disadvantage was 1.29 for hepatoblastoma Open
Statement Hazard ratio for socioeconomic disadvantage was 2.02 for Wilms tumor Open
Quotation Pediatric oncology outcomes aren't just about tumor biology or treatment received. It's about the social determinants of health for these children as well. Open
Statement Pediatric oncology outcomes depend on tumor biology, treatment received, and social determinants of health Open
Statement Identifying socioeconomic risk factors is necessary to close equity gaps and improve survival for all children with solid tumors Open

Long-Term Follow-Up of Surgical Outcomes for Patients With Wilms Tumor and Neuroblastoma

Quotation You just surgically treated your patient with Wilms tumor or neuroblastoma. Now what? Open
Statement This single institution cohort followed survivors for a mean of 27 years after open oncologic resection for Wilms tumor and neuroblastoma Open
Statement 14% of patients required a repeat laparotomy Open
Statement The most common indications for repeat laparotomy were small bowel obstruction or tumor recurrence Open
Statement In Wilms tumor, obstruction typically occurred within the first year Open
Statement In neuroblastoma, obstruction often developed more than a decade later, well beyond routine follow-up Open
Statement Radiation dose was not associated with re-operation risk Open
Statement Secondary malignancy was uncommon in this cohort Open
Statement Hypertension after nephrectomy was not increased compared to population norms Open
Statement Scoliosis has multi-factorial contributors including surgery and possibly radiation Open
Statement Scoliosis occurred in roughly 10 to 13% of patients, higher than the general population Open
Quotation The takeaway is that surgical care does not end at resection. Open
Statement Even decades after treatment, these patients remain at risk for late complications that warrant long-term counseling and follow-up Open