Zhang Jing

68 statements · 1 topic · summaries given as host listed separately

Biliary Atresia · guest expert

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And I think, uh, nowadays it's CSI procedure is still the first line treatment for bilireatresia, but as we can see, there's some patients, um, could not achieve their jaundice clearance and their um they couldn't live long for uh with their native liver.
quote · Biliary Atresia
Recently, it has been reported that MMP 7 can help precisely discriminate BA from other cholecystic diseases at a cutoff value of around 20.
quote · Biliary Atresia

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Zhang's statements about Biliary Atresia 68 statements

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Jingying Jiang, MD - Best of the Best in Pediatric Surgery 2024

Statement Biliary atresia is a severe liver disease characterized by fibro-inflammatory destruction of bile ducts. Open
Quotation Breatresia is a severe liver disease characterized by fibro inflammatory destruction of bi ducts. Open
Quotation Breatresia is a severe liver disease characterized by fibro inflammatory destruction of bi ducts. Open
Statement Biliary atresia is a severe liver disease characterized by fibro-inflammatory destruction of bile ducts. Open
Statement MMP-7 can help precisely discriminate BA from other cholestatic diseases at a cutoff value of around 20 ng/mL. Open
Quotation Recently, it has been reported that MMP 7 can help precisely discriminate BA from other cholecystic diseases at a cutoff value of around 20. Open
Statement 5 to 10% of BA patients have false negative MMP-7 levels. Open
Quotation However, there were Still 5 to 10% of patients with force negative MMP7 whose characteristics and prognosis remain unknown. Open
Statement The study reviewed 329 BA patients who underwent Kasai procedure from 2020 to 2022. Open
Statement The study reviewed 329 BA patients who underwent Kasai procedure from 2020 to 2022. Open
Statement Patients were divided into low MMP-7 and high MMP-7 groups based on preoperative MMP-7 levels of 20-25 ng/mL. Open
Statement Patients were divided into low MMP-7 and high MMP-7 groups based on preoperative MMP-7 levels of 20-25 ng/mL. Open
Statement The median MMP-7 level for low MMP-7 group was 20.19 ng/mL compared with 66.55 ng/mL for the high MMP-7 group. Open
Statement The median MMP-7 level for low MMP-7 group was 20.19 ng/mL compared with 66.55 ng/mL for the high MMP-7 group. Open
Statement Preoperative gamma-GT and direct bilirubin in the low MMP-7 group were significantly lower than those in the high MMP-7 group. Open
Statement Preoperative gamma-GT and direct bilirubin in the low MMP-7 group were significantly lower than those in the high MMP-7 group. Open
Statement Fibrosis stages were significantly different between the low and high MMP-7 groups. Open
Statement Fibrosis stages were significantly different between the low and high MMP-7 groups. Open
Statement Three-month jaundice clearance rate was 46.91% for the high MMP-7 group and 29.73% for the low MMP-7 group. Open
Statement Three-month jaundice clearance rate was 46.91% for the high MMP-7 group and 29.73% for the low MMP-7 group. Open
Statement Six-month jaundice clearance rate was 54.51% for the high MMP-7 group and 32.14% for the low MMP-7 group. Open
Statement Six-month jaundice clearance rate was 54.51% for the high MMP-7 group and 32.14% for the low MMP-7 group. Open
Statement A total of 90 patients in the low MMP-7 group and 112 patients in the high MMP-7 group died or underwent liver transplantation by the latest follow-up. Open
Statement A total of 90 patients in the low MMP-7 group and 112 patients in the high MMP-7 group died or underwent liver transplantation by the latest follow-up. Open
Statement One-year native liver survival rate was 29.63% for the low MMP-7 group and 53.02% for the high MMP-7 group. Open
Statement One-year native liver survival rate was 29.63% for the low MMP-7 group and 53.02% for the high MMP-7 group. Open
Quotation So taken together, around 10% of VA patients have low 7 MMP 7 levels. Open
Statement Around 10% of BA patients have low MMP-7 levels. Open
Statement Around 10% of BA patients have low MMP-7 levels. Open
Quotation So taken together, around 10% of VA patients have low 7 MMP 7 levels. Open
Statement Low gamma-GT levels correlated with more severe liver injury and poor outcomes in a previous study. Open
Quotation Our previous study suggested. Low gamma GT levels correlated with more severe liver injury and poor outcomes. Open
Statement BA patients in the low MMP-7 group had a lower jaundice clearance rate and native liver survival rate. Open
Statement BA patients in the low MMP-7 group had a lower jaundice clearance rate and native liver survival rate. Open
Quotation So more subjects and a long-term follow-up are warranted to determine whether this could be listed as a new clinical subtype of BA. Open
Quotation So more subjects and a long-term follow-up are warranted to determine whether this could be listed as a new clinical subtype of BA. Open
Statement Some patients lost to follow-up within 3 months were excluded from final analysis. Open
Quotation One of our limitations in this study was the period of follow-up maybe not long enough for some patients, ranging from 3 months to 3 years, and some patients lost follow up within 3 months and were excluded from final analysis which may Introduceed buyers to the results. Open
Quotation One of our limitations in this study was the period of follow-up maybe not long enough for some patients, ranging from 3 months to 3 years, and some patients lost follow up within 3 months and were excluded from final analysis which may Introduceed buyers to the results. Open
Statement Some patients lost to follow-up within 3 months were excluded from final analysis. Open
Statement The follow-up period ranged from 3 months to 3 years. Open
Statement The follow-up period ranged from 3 months to 3 years. Open
Statement Patients did not take MMP-7 measurements post-Kasai procedure in this study. Open
Quotation Finally, the patients did not take MMP 7 measurements post Kasa procedure. Open
Quotation Finally, the patients did not take MMP 7 measurements post Kasa procedure. Open
Statement Patients did not take MMP-7 measurements post-Kasai procedure in this study. Open
Quotation However, the dynamic analysis of MMP 7 levels postoperatively will be meaningful in further understanding the mechanism. Open
Quotation However, the dynamic analysis of MMP 7 levels postoperatively will be meaningful in further understanding the mechanism. Open
Quotation So, the MMP 7 measurement is based on the 7, and, uh, it is based on the method of Eliza. Open
Statement MMP-7 measurement is based on ELISA method. Open
Statement MMP-7 measurement is based on ELISA method. Open
Quotation So, the MMP 7 measurement is based on the 7, and, uh, it is based on the method of Eliza. Open
Statement MMP-7 testing is not very popular in every hospital in China, just in some institutions. Open
Statement MMP-7 testing is not very popular in every hospital in China, just in some institutions. Open
Statement MMP-7 testing costs about 1000 RMB per patient in China. Open
Statement MMP-7 testing costs about 1000 RMB per patient in China. Open
Quotation So it's cost about uh I think 1000 RMB for each patient, uh, each measurement. Open
Quotation So it's cost about uh I think 1000 RMB for each patient, uh, each measurement. Open
Statement Some BA patients could not achieve jaundice clearance and could not live long with their native liver after Kasai. Open
Statement Some BA patients could not achieve jaundice clearance and could not live long with their native liver after Kasai. Open
Quotation And I think, uh, nowadays it's CSI procedure is still the first line treatment for bilireatresia, but as we can see, there's some patients, um, could not achieve their jaundice clearance and their um they couldn't live long for uh with their native liver. Open
Quotation And I think, uh, nowadays it's CSI procedure is still the first line treatment for bilireatresia, but as we can see, there's some patients, um, could not achieve their jaundice clearance and their um they couldn't live long for uh with their native liver. Open
Statement Kasai procedure is still the first line treatment for biliary atresia. Open
Statement Kasai procedure is still the first line treatment for biliary atresia. Open
Quotation So someday if we are definitely uh clear about their mechanism of MMP 7 in bilireresia, maybe someday, the patients with low MMP 7 can go directly for liver transplantation. Open
Statement If the mechanism of MMP-7 in biliary atresia becomes clear, patients with low MMP-7 might go directly for liver transplantation in the future. Open
Quotation So someday if we are definitely uh clear about their mechanism of MMP 7 in bilireresia, maybe someday, the patients with low MMP 7 can go directly for liver transplantation. Open
Statement If the mechanism of MMP-7 in biliary atresia becomes clear, patients with low MMP-7 might go directly for liver transplantation in the future. Open

Summaries Zhang gave as host · 6 summaries

Recaps of other experts' statements, not Zhang's own clinical position.

Summaries Zhang gave as host · Biliary Atresia 6 summaries

Open the Biliary Atresia collection →

Jingying Jiang, MD - Best of the Best in Pediatric Surgery 2024

Host summary Zhang Jing summarizing a resource: MMP-7 can help precisely discriminate BA from other cholestatic diseases at a cutoff value of around 20 ng/mL. Open
Host summary Zhang Jing summarizing a resource: Recently, it has been reported that MMP 7 can help precisely discriminate BA from other cholecystic diseases at a cutoff value of around 20. Open
Host summary Zhang Jing summarizing a resource: 5 to 10% of BA patients have false negative MMP-7 levels. Open
Host summary Zhang Jing summarizing a resource: However, there were Still 5 to 10% of patients with force negative MMP7 whose characteristics and prognosis remain unknown. Open
Host summary Zhang Jing summarizing a resource: Our previous study suggested. Low gamma GT levels correlated with more severe liver injury and poor outcomes. Open
Host summary Zhang Jing summarizing a resource: Low gamma-GT levels correlated with more severe liver injury and poor outcomes in a previous study. Open