Disruption of enterohepatic Circulation of Bile acids ameliorates small bowel resection associated hepatic injury

Disruption of the enterohepatic circulation of bile acids is beneficial for the liver

The study was conducted at Saint Louis Children's Hospital and aimed to elucidate the driving force behind hepatic injury following bowel resection

The study used three groups of mice: sham, 50% with proximal or duodenal resection, and 50% with distal resection or resection of the ileocecal valve

Tissue samples were taken at the second and tenth post-operative weeks

Mice with distal resection showed less hepatic oxidative stress compared to proximal resection

Mice with distal resection showed a more hydrophilic bile acid profile compared to proximal resection

Ileal resection could lead to less hepatic injury