Glycopyrrolate for Anastomtic Dehiscence in Esophageal Atresia

The study included 297 patients over a 10 year period that underwent esophageal atresia repair

Of the 297 esophageal atresia repairs, there were 42 leaks, approximately 14%

The 42 patients with leaks were prospectively randomized into two groups of 21 each, one receiving glycopyrrolate and the other receiving saline placebo

The observer was blinded to which treatment group the patient was in

Chest tube output was 124 mL in the glycopyrrolate treatment group compared to 370 mL in the placebo group

Leak resolution was accomplished in 76% of the glycopyrrolate treatment group compared to 29% of the placebo group

Oral feeding was achieved in 71% of the glycopyrrolate treatment group compared to only 14% of the placebo group