StayCurrentMD · Gastroesopheal Reflux Disease
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Podcast33 min·Published Dec 2016Older

Gastroesopheal Reflux Disease

With Dr. Michael Rosen · hosted by Dr. Jeff Ponsky

Chapter 1 of 11 · Fundamentals

Introduction

Introduction and Initial Patient Presentation

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What the experts said35 expert statements · 2 host summaries
PPIs reduce gastric acid secretion more effectively than H2 blockers and are more convenient as once-daily dosing
ClinicalMichael Rosen
Mounting data shows that lifetime proton pump inhibitor use has consequences
ClinicalMichael Rosen
Minimum workup for patients with reflux symptoms requiring chronic PPI therapy includes endoscopy to assess esophagitis and rule out Barrett's esophagus
GuidelineMichael Rosen
Barrett's esophagus may be subtle and asymptomatic, with risk of progression through low-grade and high-grade dysplasia to gastric cancer
ClinicalJeff Ponsky
Long-term PPI use in women is associated with osteoporosis risk
EpidemiologicalMichael Rosen
For PPI efficacy, the medication should be taken within 30 minutes before a meal, not at night before bed or in the morning while skipping breakfast
ClinicalMichael Rosen
The primary reason for obtaining manometry before anti-reflux surgery is to rule out achalasia, because wrapping a patient with achalasia destroys esophageal function
ClinicalMichael Rosen
Routine manometry before reflux surgery identifies previously undiagnosed achalasia cases that would have been missed without systematic testing
ClinicalMichael Rosen
Patients with achalasia can present with heartburn symptoms due to stasis and fermentation of food in the esophagus
ClinicalMichael Rosen
Manometry findings guide fundoplication type: distal esophageal amplitudes help determine whether to perform a full Nissen wrap versus a partial Toupet wrap
ClinicalMichael Rosen
One disadvantage of laparoscopic fundoplication compared to open surgery is reduced scar tissue formation; full mediastinal dissection helps create scarring to reduce recurrence rates
ClinicalMichael Rosen
Nissen fundoplication technique is highly variable among surgeons with poor standardization, making it difficult to reproduce research data
OpinionMichael Rosen
The geometry of the Nissen wrap is the most important part of the operation; incorrect geometry (grabbing posterior greater curve too low) can trap fundus above the wrap
ClinicalJeff Ponsky
A common mistake in Nissen fundoplication is making the wrap too long, which increases postoperative dysphagia; optimal wrap length is approximately 2 centimeters
ClinicalMichael Rosen
Experienced surgeons no longer routinely use a 56 French bougie during hiatal closure, as it becomes less necessary with experience and carries perforation risk
OpinionMichael Rosen
For patients with weak esophageal peristalsis (amplitude below 20 mmHg) or connective tissue disease, a Toupet (270-degree posterior) fundoplication is preferred over full Nissen to avoid creating pseudoachalasia
ClinicalMichael Rosen
The best operation to prevent reflux is a Nissen fundoplication, but in patients with poor esophageal motility, the esophageal pump cannot overcome the barrier, necessitating a partial wrap
ClinicalMichael Rosen
Toupet fundoplication is made slightly longer than Nissen (2.5 to almost 3 centimeters) with three sutures on either side, esophagus to stomach
ClinicalMichael Rosen
Anti-reflux surgery changes swallowing mechanics, stomach function, and acid movement; patients must understand these changes are permanent
ClinicalMichael Rosen
Fundoplication wraps are tightest immediately after surgery and loosen over time; early dysphagia is expected and normal
ClinicalMichael Rosen
A patient with no dysphagia two weeks after Nissen fundoplication is concerning because it indicates the wrap was made too loose and will likely fail long-term
ClinicalMichael Rosen
Endoscopic intervention for postoperative dysphagia should not be considered until three months postoperatively, even if the patient can only tolerate liquids, as long as there is no anatomic problem
ClinicalMichael Rosen
Pseudoachalasia after fundoplication presents with dilated esophagus, bird's beak appearance, and manometry showing absent peristalsis with non-relaxing LES, likely due to wrap being too tight causing esophageal burnout
ClinicalMichael Rosen
Treatment options for pseudoachalasia include taking down the Nissen, performing Heller myotomy with Dor fundoplication, or converting to Toupet wrap with long Heller myotomy
ClinicalMichael Rosen
For reoperative foregut surgery, the best approach is to plan to completely take down the wrap and start over, though this may not always be necessary or possible
OpinionMichael Rosen
For morbidly obese patients (BMI over 35) with GERD, gastric bypass is preferred over Nissen fundoplication as the primary operation because Nissen does not work well in this population
ClinicalMichael Rosen
Before reoperative anti-reflux surgery, complete re-evaluation is essential including 48-hour Bravo study for symptom correlation, repeat manometry, and gastric emptying study
GuidelineMichael Rosen
Nausea and vomiting as prominent symptoms in GERD patients are red flags suggesting delayed gastric emptying; these patients require careful evaluation before proceeding with fundoplication
ClinicalMichael Rosen
In reoperative foregut surgery, prior port placement reveals the extent of original dissection: umbilical incision indicates no chest dissection was performed; five ports with lowest 5 cm from umbilicus indicates extensive original dissection
ClinicalMichael Rosen
The first goal in reoperative fundoplication is to identify the right crus at its base, which provides orientation and prevents drifting into the inferior vena cava
ClinicalMichael Rosen
Sharp dissection is preferred over harmonic scalpel when taking liver off the wrap in reoperative surgery, accepting some bleeding that can be compressed with the retractor paddle
ClinicalMichael Rosen
Most primary fundoplications fail to create adequate scar tissue in the chest; if struggling with reoperative dissection below, the second approach is to enter the chest wherever possible and work back down
ClinicalMichael Rosen
Reoperative foregut surgery requires identifying named structures and systematic dissection rather than creating spaces, or the surgeon will quickly become lost
ClinicalMichael Rosen
If anterior vagus nerve is injured during reoperative fundoplication but posterior vagus is intact, observation is appropriate; postoperative upper GI on day 1-2 assesses gastric emptying
ClinicalMichael Rosen
For delayed gastric emptying after vagal injury, early Botox injection to the pylorus is preferred over pyloroplasty unless both vagal nerves were clearly transected
ClinicalMichael Rosen
The 'triangle of air' below the esophagus after hiatal closure, described by Ron Hinder, indicates appropriate hiatal tightness
Host summaryJeff Ponsky summarizes what Dr. Michael Rosen said · not cited in answers
David Ratner described an approach of taking down the Nissen, doing a long Heller, and converting to Toupet to open the wrap at 180 degrees on both sides
Host summaryJeff Ponsky summarizes what Dr. Michael Rosen said · not cited in answers