From
StayCurrentMD
Trauma II: Solid Organ Injury
With Dr. David Notrica · hosted by Dr. Todd Ponsky & Dr. Mark McCollum
Part of
Hemorrhagic Shock 4 items
Chapter 1 of 8 · Evidence & Research
ATOMIC overview
Introduction and ATOMIC Study Background
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What the experts said
ATOMIC consortium started around 2010 as a multi-center prospective study, initially with 5 hospitals expanding to 10, to develop evidence-based algorithms for solid organ injury management
Hypotension is a late finding in pediatric hemorrhagic shock; almost half of patients requiring early transfusion are not hypotensive
When a hypovolemic pediatric patient arrives, you know they have bled but often cannot determine if they are still bleeding until you give them blood and observe their response
Shock index pediatric adjusted (SIPAA) cutoffs: ages 4-6 greater than 1.2, ages 7-12 greater than 1.0, ages 13+ greater than 0.9. Shock index identifies patients NOT in shock with high sensitivity but has lower specificity
After 20 mL/kg of crystalloid, blood transfusion should be initiated if non-operative management is desired and good outcomes are the goal
Viscoelastic assays (TEG/ROTEM) for directed component therapy are theoretically superior to ratio-driven massive transfusion, but definitive pediatric evidence requires a randomized controlled trial comparing the approaches
Angioembolization is safe in pediatric blunt solid organ injury. For splenic injury, no embolized patients in the ATOMIC study went on to fail non-operative management
Many patients with contrast extravasation on CT will stop bleeding spontaneously without angioembolization
Many patients with hepatic injury who underwent angioembolization still required laparoscopy or washout for bile complications or hemoperitoneum management, though embolization was helpful in converting active bleeding to manageable complications
Grade 5 solid organ injuries should be admitted to ICU based on injury grade alone, but grade 1-4 injuries can be managed on the floor if hemodynamically stable
In renal injury, bed rest makes no difference in outcomes whether patients are walking or on strict bed rest
Hemodynamically stable patients with no signs of bleeding can be safely discharged after 18 hours of observation, as patients who fail non-operative management fail early
Serial hemoglobin monitoring is not necessary for stable patients; hemoglobin can decrease due to lab error, dilution from IV fluids, or incorrect blood draw technique. Physical examination and vital signs are superior indicators of ongoing bleeding
Half of patients who fail non-operative management do so because they develop peritonitis, not because of continued bleeding
Telephone follow-up is effective for low-grade injuries; many patients with low-grade injuries never showed for in-person clinic appointments, and telephone follow-up prevents additional missed school days
In-person follow-up visits for solid organ injury have limited utility; patients who needed additional imaging or therapy all presented back to the emergency room with symptoms rather than being identified at routine follow-up
Studies performing routine ultrasounds found many pseudoaneurysms, but the number was discordant with actual delayed bleeding or complications, indicating that asymptomatic pseudoaneurysms rarely lead to clinically significant problems (estimated less than 10%, possibly much lower)
Activity restrictions default to APSA recommendation of grade-plus-two-weeks (e.g., grade 4 injury restricted for 6 weeks), though this is based on expert opinion rather than scientific evidence
Children with solid organ injury can return to school but should change classes 5 minutes before other students to avoid hallway contact and should not participate in gym or physical education
Early recurrent hypotension (patient responds to initial resuscitation, becomes stable, then becomes unstable again before reaching ICU) represents failure of non-operative management and requires operation or angioembolization
Arkansas researchers (Sam Smith) and Sean St. Peter demonstrated that patients can be managed based on hemodynamic status rather than CT injury grade, challenging the original grade-based consensus approach developed by Steve Stilanos
ATLS previously recommended 60 mL/kg of crystalloid before blood transfusion, but adult literature showed excessive crystalloid dilutes the benefit of 1:1:1 resuscitation and reduces non-operative management success
John Holcomb's work showed that early blood transfusion reduces the number of patients progressing to massive transfusion protocol requirements
Bed rest was never included in the original APSA protocols for solid organ injury management, though it became culturally embedded in practice without evidence
The threshold for failure of non-operative management is 40 mL/kg of all blood products, based on data from the military experience showing increased need for operation and mortality above this threshold