Utility of Fluorescence In Situ Hybridization as a Fetal Surgery Eligibility Criterion for....
hosted by Lizzy Lee, PA-C
Part of
Fetal Surgery 30 items
Chapter 1 of 1 · Evidence & Research
FISH Testing Utility in Fetal Surgery Screening
Expert statements on this page
No expert statements were drawn from this page.
Host summaries · secondary, not cited in answers
Educational content from recorded physician discussions — not medical advice. Talk to your (or your child's) care team about your situation.
What the experts said
Many centers require genetic testing to rule out chromosome abnormalities before fetal surgery, even when ultrasounds and blood tests already look reassuring
A study reviewed nearly 1000 pregnancies evaluated for fetal surgery
When imaging and cell-free DNA screening showed low risk for aneuploidy, the FISH test matched those results 100% of the time
For low-risk pregnancies, FISH did not provide any new information that changed surgery candidacy
In carefully selected low-risk cases, non-invasive screening may be enough, potentially avoiding the FISH procedure