Pediatric Gastroesophageal Reflux Disease
The vast majority of kids who have vomiting, respiratory symptoms, and wheezing are more likely to have oropharyngeal dysphagia and aspiration during swallowing than gastroesophageal reflux.
In infants fed every 2 to 3 hours, milk remains in the stomach for up to 2–3 hours; acid production only begins after 3 hours, so infants reflux non-acidic gastric content.
Proton pump inhibitors are not beneficial in children under the age of 1 because they reflux non-acidic milk, not acid.
Studies have shown that both H2 blockers and PPIs increase the risk of sepsis, UTIs, necrotizing enterocolitis, pneumonia, pharyngitis, upper respiratory infections, GI bugs, and C. diff in infants.
Eosinophilic esophagitis is found in about 10% of kids under age 5 who are scoped for respiratory symptoms.
In children under 5, the most common presentation of eosinophilic esophagitis is chronic cough; the second most common is vomiting or failure to thrive.
In older kids, eosinophilic esophagitis presents with chest pain, food impactions, and dysphagia.
You really need to scope every kid before they would get a Nissen because you don't want to wrap a kid who has eosinophilic esophagitis.
Cites a guidelineRachel Rosen10:54
About 60 to 70% of kids with eosinophilic esophagitis are allergic to dairy.
Macrolides (erythromycin) are motilin agonists that make the antrum of the stomach contract and can help with vomiting; they also have an anti-inflammatory effect on the airway and lungs.
There are no great normal values for the number of reflux episodes in pediatric patients, so the best use of a probe is to correlate symptoms with reflux episodes.
The majority of kids will outgrow their oropharyngeal dysphagia by 3 to 4 months of age.
In kids with oropharyngeal dysphagia in the NICU, about 75% will get the NG tube out and not need to go on to gastrostomy.
When we looked at our own data at Boston Children's, once a gastrostomy goes in in children that aspirate from oropharyngeal dysphagia, their rates of hospitalization are about 15 times higher than if you just fed them by mouth, even in kids who aspirate all textures.
An upper GI is really not a good study for reflux; it doesn't document reflux very well because if the child's not refluxing right when the x-ray is taken, it won't show reflux.
In a study of patients who had upper GI and pH studies, the upper GI did not help with diagnosing reflux, but it did help identify an anatomical problem in about 4% of patients.
New GERD guidelines (joint North America and Europe) recommend treating with PPI for 2 months, then attempting to wean; if unable to wean, restart the drug, but the goal should be to try to wean ideally 2 times a year.
Cites a guidelineRachel Rosen43:42
If you have reflux beyond the age of 3 or 4, you're likely to continue to have it long term.
In Kansas City's prospective randomized trial of 107 patients, neither group required a redo fundoplication for a slipped wrap; the primary reason for redo historically was transmigration of the wrap into the chest.
By doing minimal mobilization and not disrupting the phrenoesophageal membrane, we were able to drop our transmigration rate from 12% to 5%, and in our final study there was zero recurrence and zero redo fundoplication rate in both groups.
The surgical message is that we need to do less rather than more dissection around the GE junction to prevent wrap transmigration.
You've got to know where the left gastric artery is, and you've got to be sure that you are cephalad to that to ensure the wrap is at the level of the lower esophagus, not the stomach.
When you're looking at the post-fundoplication patient, if they have a G tube, you have to image them both ways: putting barium through the G tube and also giving them barium from above via a nasoesophageal tube to see if the esophagus is emptying.
A study out of Cincinnati showed that blenderized feeds are a really effective therapy for treatment of post-fundoplication retching.
We use a lot of erythromycin in babies who have respiratory symptoms; macrolides are motilin agonists and also have an anti-inflammatory effect for the airway and lungs.
Pyloric Botox works not only for delays in emptying but also with the sensory component that triggers retching.
Cyproheptadine (periactin) helps with gastric accommodation and can control retching in kids.
When you look at kids that tend to do the worst after Nissen, it's the kid who had a Nissen for pulmonary reasons; if they're aspirating during swallowing, their saliva pools in the esophagus over the Nissen and they continue to aspirate, so they gag, retch, and cough all the time.
The kids who are the most miserable post-Nissen are the kids that were retching pre-op, because they retch a lot post-op too.
Using an esophageal bougie at the time of fundoplication has resulted in very little need for postoperative dilation; in all our prospective studies, we've dilated one or two patients.