Colorectal Cancer
Everything in the library about colorectal cancer — built automatically from the recorded discussions that name it
Educational content from recorded physician discussions — not medical advice. Always talk to your child's care team about your child's situation.
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Evidence & Research
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Best of the Best Gen Surg - Development of postoperative local tumors and distant metastases in diet, genetics and microbiome-dependent in a mouse model of colorectal cancer recurrence - Dr. Morgan
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Listen to Ryan Morgan gave his presentation of "Development of postoperative local tumors and distant metastases in diet, genetics and microbiome-dependent in a mouse model of colorectal cancer recurrence" at the first ever Best of the Best
video12:40 · Sep 2022
In-Depth Reviews
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Colorectal Cancer
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An interactive discussion about colorectal cancer between Jeffrey Ponsky, MD and Conor Delaney, MD, PhD. Dr. Delaney, is the chairman of the Digestive Disease
podcast26:42 · Jul 2026
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Every expert statement below comes from the recorded discussions, with its speaker and moment.
Best of the Best Gen Surg - Development of postoperative local tumors and distant metastases in diet, genetics and microbiome-dependent in a mouse model of colorectal cancer recurrence - Dr. Morgan
Colorectal cancer is a leading cause of cancer deaths, particularly in cases of recurrence.
epidemiologicalRyan Morgan0:45 ↗
Traditional paradigms suggest recurrences are due to either incomplete resection or occult metastases left behind at the time of surgery.
host_summaryRyan Morgan0:45 ↗
Exfoliated cancer cells in the lumen of the bowel may be a source of recurrence.
host_summaryRyan Morgan0:58 ↗
In the 1980s, UMLB showed that exfoliated cancer cells are present and viable at the time of surgery.
host_summaryRyan Morgan1:04 ↗
Experimental cells could cross a watertight anastomosis in a mouse model.
host_summaryRyan Morgan1:09 ↗
Rectal washout decreases rates of local recurrence after rectal cancer resection.
host_summaryRyan Morgan1:14 ↗
When the primary colorectal tumor is resected, exfoliated cells remain behind within the lumen of the bowel and interact with the anastomotic microenvironment.
clinicalRyan Morgan1:39 ↗
Multiple factors can influence the anastomotic environment, including diet, the microbiome, and the tumor genetic background.
clinicalRyan Morgan1:48 ↗
A high-fat diet and its impact on the microbiome would alter the anastomotic environment and change the metastatic potential of cells.
clinicalRyan Morgan2:04 ↗
AKPT and KPN organoid cell lines demonstrate a wide range of metastatic potential in animal models.
host_summaryRyan Morgan2:15 ↗
AKPT mice showed significantly higher rate of tumor formation with a high-fat diet compared to mice given a chow diet by 56 days.
clinicalRyan Morgan3:35 ↗
KPN mice showed no significant difference in tumor formation based on diet, with an opposite trend towards higher rates in the chow diet.
clinicalRyan Morgan3:46 ↗
AKPT mice given a high-fat diet had significantly decreased survival compared to those on a chow diet.
clinicalRyan Morgan4:08 ↗
KPN mice did not show any similar survival trend, suggesting that response to diet was at least in part based on the organoid genetic background.
clinicalRyan Morgan4:14 ↗
In germ-free mice, the high-fat diet-associated microbiome significantly increased the rate of postoperative tumor development (40% vs 10-12% in control and chow FMT groups).
clinicalRyan Morgan4:57 ↗
Two-week diet reversal period was insufficient; mice in the reversal group continued to have poor survival and high tumor rates similar to the high-fat diet group.
clinicalRyan Morgan5:50 ↗
Six-week diet reversal resulted in significantly increased survival and tumor rate similar to chow-fed mice, suggesting the response to diet and its reversal was time dependent.
clinicalRyan Morgan6:01 ↗
High-fat diet mice showed derangement of microbiome with overabundance of Alobaum and bloom of pathogenic bacteria such as Proteus, E. coli, and Shigella on postoperative day 7.
clinicalRyan Morgan6:30 ↗
The diet reversal group microbiome composition closely mirrored the chow group both in baseline composition and in response to surgery.
clinicalRyan Morgan6:45 ↗
Preoperative diet manipulation reduces tumor formation, suggesting a clinically relevant role for diet rehabilitation in colorectal cancer treatment.
opinionRyan Morgan7:23 ↗
The no-touch isolation technique of Turnbull was important in demonstrating the need to avoid handling the tumor.
host_summary8:20 ↗
Combined mechanical and antibiotic bowel preparation preoperatively decreases rates of colorectal cancer recurrence.
host_summaryRyan Morgan9:23 ↗
Preliminary in vitro data shows AKPT cells have more proliferative response to secondary bile acids (like deoxycholic acid) compared to KPN cells.
clinicalRyan Morgan11:05 ↗
Secondary bile acids and deoxycholic acid metabolites are exclusively bacterially produced.
clinicalRyan Morgan11:05 ↗
Colorectal Cancer
Colonoscopy is still the best test available for colon cancer detection, finding the vast majority of cancers and polyps, though not perfect.
clinicalConor Delaney1:15 ↗
Serrated adenomas (previously misclassified as hyperplastic polyps) have good evidence of genetic predisposition and tie into many family cancer syndromes.
clinicalConor Delaney2:03 ↗
Serrated polyps have a very high risk of cancer and require family assessment to determine if patients have a family cancer syndrome.
clinicalConor Delaney2:03 ↗
Serrated adenomas are often flat and difficult to see; retroflexion in the cecum is useful because they are often on the inferior or superior side of the valve or on folds.
clinicalConor Delaney3:26 ↗
Six centimeters from the anal verge can be mid-rectum in a small patient (90-pound, 80-year-old female) or close to the dentate line in a large patient (6'6", 300 pounds).
clinicalConor Delaney4:59 ↗
Distal margin requirements for rectal resection: 5 centimeters if possible, 2 centimeters if possible, and for very lowest tumors perhaps 1 centimeter as long as they are not poorly differentiated.
guidelineConor Delaney4:59 ↗
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